Clinical Laboratory, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Clinical Biological Resource Bank, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Dis Markers. 2019 Jan 3;2019:2849695. doi: 10.1155/2019/2849695. eCollection 2019.
Kawasaki disease (KD) is an acute vasculitis disease that commonly causes acquired heart disease in children. Coronary artery aneurysm (CAA) is a major complication of KD. However, the pathogenesis of KD remains unclear. The results of a genome-wide association study (GWAS) showed that two functional single-nucleotide polymorphisms (SNPs; rs699A>G and rs5050T>G) in the angiotensinogen (AGT) gene were related to cardiovascular disease susceptibility. The purpose of our study was to estimate the relationship between the two GWAS-identified AGT gene polymorphisms and the risk of CAA in Southern Chinese children with KD.
We genotyped the two AGT gene polymorphisms (rs699A>G and rs5050T>G) in 760 KD cases and 972 healthy controls. We used the odds ratios (ORs) and 95% confidence intervals (CIs) to estimate the degree of the associations.
These two AGT gene polymorphisms were not associated with a risk of KD relative to the controls, but after adjusting for sex and age, the carriers of the rs5050G allele with TG/GG vs TT had an adjusted OR = 1.56, 95% CI = 1.01-2.41, and = 0.044 relative to the carriers of the rs5050TT genotype. The susceptibility to CAA was more predominant in KD patients younger than 12 months old.
Our results indicate that the AGT gene polymorphism rs5050T>G may increase the risk of CAA in children with KD, especially those who are younger than 12 months. These results need to be verified by a validation study with a larger sample size.
川崎病（KD）是一种常见于儿童的急性血管炎疾病，可导致后天性心脏病。冠状动脉瘤（CAA）是 KD 的主要并发症。然而，KD 的发病机制仍不清楚。全基因组关联研究（GWAS）的结果表明，血管紧张素原（AGT）基因中的两个功能性单核苷酸多态性（SNP；rs699A>G 和 rs5050T>G）与心血管疾病易感性有关。本研究旨在评估这两个 GWAS 确定的 AGT 基因多态性与中国南方儿童 KD 患者 CAA 风险之间的关系。
我们对 760 例 KD 病例和 972 例健康对照进行了两个 AGT 基因多态性（rs699A>G 和 rs5050T>G）的基因分型。我们使用比值比（OR）和 95%置信区间（CI）来估计关联程度。
这两个 AGT 基因多态性与 KD 相对于对照组的发病风险无关，但在调整性别和年龄后，与 rs5050T 等位基因携带者 TG/GG 与 TT 相比，调整后的 OR = 1.56，95%CI = 1.01-2.41，P = 0.044。该基因多态性与 CAA 的易感性在年龄小于 12 个月的 KD 患者中更为明显。
我们的结果表明，AGT 基因多态性 rs5050T>G 可能增加 KD 患儿 CAA 的发病风险，尤其是年龄小于 12 个月的患儿。这些结果需要通过更大样本量的验证研究来验证。
