Goel Mishita, Dhillon Shubhkarman, Kumar Sarwan, Tegeltija Vesna
Department of Internal Medicine, Ascension Providence Rochester Hospital/Wayne State University School of Medicine, 1101 W University Drive, Rochester, MI, 48307, USA.
J Med Case Rep. 2021 Feb 9;15(1):49. doi: 10.1186/s13256-021-02666-z.
Cardiac stress testing is a validated diagnostic tool to assess symptomatic patients with intermediate pretest probability of coronary artery disease (CAD). However, in some cases, the cardiac stress test may provide inconclusive results and the decision for further workup typically depends on the clinical judgement of the physician. These decisions can greatly affect patient outcomes.
We present an interesting case of a 54-year-old Caucasian male with history of tobacco use and gastroesophageal reflux disease (GERD) who presented with atypical chest pain. He had an asymptomatic electrocardiogram (EKG) stress test with intermediate probability of ischemia. Further workup with coronary computed tomography angiography (CCTA) and cardiac catheterization revealed multivessel CAD requiring a bypass surgery. In this case, the patient only had a history of tobacco use but no other significant comorbidities. He was clinically stable during his hospital stay and his testing was anticipated to be negative. However to complete workup, cardiology recommended anatomical testing with CCTA given the indeterminate EKG stress test results but the results of significant stenosis were surprising with the patient eventually requiring coronary artery bypass grafting (CABG).
As a result of the availability of multiple noninvasive diagnostic tests with almost similar sensitivities for CAD, physicians often face this dilemma of choosing the right test for optimal evaluation of chest pain in patients with intermediate pretest probability of CAD. Optimal test selection requires an individualized patient approach. Our experience with this case emphasizes the role of history taking, clinical judgement, and the risk/benefit ratio in deciding further workup when faced with inconclusive stress test results. Physicians should have a lower threshold for further workup of patients with inconclusive or even negative stress test results because of the diagnostic limitations of the test. Instead, utilizing a different, anatomical test may be more valuable. Specifically, the case established the usefulness of CCTA in cases such as this where other CAD diagnostic testing is indeterminate.
心脏负荷试验是一种经过验证的诊断工具,用于评估有冠状动脉疾病(CAD)中度预检概率的有症状患者。然而,在某些情况下,心脏负荷试验可能会提供不确定的结果,进一步检查的决定通常取决于医生的临床判断。这些决定会极大地影响患者的预后。
我们介绍了一例有趣的病例,一名54岁有吸烟史和胃食管反流病(GERD)的白人男性,出现非典型胸痛。他进行了无症状心电图(EKG)负荷试验,缺血概率为中度。进一步通过冠状动脉计算机断层扫描血管造影(CCTA)和心脏导管检查发现多支血管CAD,需要进行搭桥手术。在这个病例中,患者仅有吸烟史,没有其他严重的合并症。他在住院期间临床稳定,预计检查结果为阴性。然而,为了完成全面检查,鉴于EKG负荷试验结果不确定,心脏病学专家建议进行CCTA解剖学检查,但严重狭窄的结果令人惊讶,患者最终需要冠状动脉旁路移植术(CABG)。
由于有多种对CAD敏感性几乎相似的非侵入性诊断测试可供使用,医生在为CAD预检概率为中度的胸痛患者选择最佳评估的正确测试时常常面临这种困境。最佳测试选择需要个体化的患者方法。我们对这个病例的经验强调了病史采集、临床判断以及在面对不确定的负荷试验结果时决定进一步检查的风险/收益比的作用。由于该测试的诊断局限性,医生对于负荷试验结果不确定甚至阴性的患者应降低进一步检查的阈值。相反,使用不同的解剖学测试可能更有价值。具体而言,该病例证实了CCTA在其他CAD诊断测试不确定的此类病例中的有用性。