Department of Twin Research and Genetic Epidemiology, School of Life Course Sciences, King's College London, London, UK.
NIHR Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust, London, UK.
Twin Res Hum Genet. 2020 Dec;23(6):316-321. doi: 10.1017/thg.2020.85.
Susceptibility to infection such as SARS-CoV-2 may be influenced by host genotype. TwinsUK volunteers (n = 3261) completing the C-19 COVID-19 symptom tracker app allowed classical twin studies of COVID-19 symptoms, including predicted COVID-19, a symptom-based algorithm to predict true infection, derived from app users tested for SARS-CoV-2. We found heritability of 49% (32-64%) for delirium; 34% (20-47%) for diarrhea; 31% (8-52%) for fatigue; 19% (0-38%) for anosmia; 46% (31-60%) for skipped meals and 31% (11-48%) for predicted COVID-19. Heritability estimates were not affected by cohabiting or by social deprivation. The results suggest the importance of host genetics in the risk of clinical manifestations of COVID-19 and provide grounds for planning genome-wide association studies to establish specific genes involved in viral infectivity and the host immune response.
感染易感性，如 SARS-CoV-2，可能受宿主基因型影响。参与 TwinsUK 计划的志愿者（n = 3261）完成了 C-19 COVID-19 症状追踪应用程序，该应用程序允许对 COVID-19 症状进行经典的双胞胎研究，包括预测 COVID-19，这是一种基于症状的算法，可以预测真正的感染，源自对 SARS-CoV-2 进行检测的应用程序用户。我们发现谵妄的遗传率为 49%（32-64%）；腹泻为 34%（20-47%）；疲劳为 31%（8-52%）；嗅觉丧失为 19%（0-38%）；错过用餐为 46%（31-60%）；预测 COVID-19 为 31%（11-48%）。遗传率估计不受同居或社会贫困的影响。研究结果表明宿主遗传学在 COVID-19 临床表现风险中的重要性，并为规划全基因组关联研究提供了依据，以确定参与病毒感染和宿主免疫反应的特定基因。
