Laboratory for Enteric NeuroScience (LENS), Translational Research Center for Gastrointestinal Disorders (TARGID), University of Leuven, Leuven 3000, Belgium.
Laboratory for Enteric NeuroScience (LENS), Translational Research Center for Gastrointestinal Disorders (TARGID), University of Leuven, Leuven 3000, Belgium
Development. 2021 Feb 8;148(3):dev182543. doi: 10.1242/dev.182543.
During embryonic development, the gut is innervated by intrinsic (enteric) and extrinsic nerves. Focusing on mammalian ENS development, in this Review we highlight how important the different compartments of this innervation are to assure proper gut function. We specifically address the three-dimensional architecture of the innervation, paying special attention to the differences in development along the longitudinal and circumferential axes of the gut. We review recent information about the formation of both intrinsic innervation, which is fairly well-known, as well as the establishment of the extrinsic innervation, which, despite its importance in gut-brain signaling, has received much less attention. We further discuss how external microbial and nutritional cues or neuroimmune interactions may influence development of gut innervation. Finally, we provide summary tables, describing the location and function of several well-known molecules, along with some newer factors that have more recently been implicated in the development of gut innervation.
在胚胎发育过程中，肠道由内在（肠）和外在神经支配。本综述聚焦于哺乳动物肠神经系统的发育，强调了这种神经支配的不同组成部分对于保证肠道正常功能的重要性。我们特别探讨了神经支配的三维结构，特别关注沿肠道的纵向和周向轴发育的差异。我们回顾了关于内在神经支配形成的最新信息，内在神经支配相当成熟，以及外在神经支配的建立，尽管它在肠道-大脑信号传递中很重要，但却受到了较少的关注。我们进一步讨论了外部微生物和营养线索或神经免疫相互作用如何影响肠道神经支配的发育。最后，我们提供了描述几个著名分子的位置和功能的总结表，以及一些最近被认为与肠道神经支配发育有关的新因素。
