Ross M G, Ervin M G, Rappaport V J, Youssef A, Leake R D, Fisher D A
Department of Obstetrics and Pediatrics, Harbor-UCLA Medical Center, UCLA School of Medicine, Torrance.
Biol Neonate. 1988;53(2):98-104. doi: 10.1159/000242768.
The ovine pregnancy has been extensively studied as a model for amniotic fluid metabolism potentially serving as a model for human oligohydramnios. However, it is recognized that the ovine pregnancy contains an allantoic fluid compartment not present in human pregnancies at term. Earlier studies in sheep suggested that the fetal urine contribution to allantoic fluid diminished at term, but without an explanation for maintenance of the significant volume of the allantoic cavity. In the present study we examined the relative fetal urine excretion of 3H-inulin into the allantoic and amniotic cavities in the near-term ovine pregnancy. Amniotic and allantoic volumes, as determined by technetium-labelled dextran and chromium-tagged erythrocyte dilution, were similar although there were significant differences in composition. The allantoic fluid compartment received an equal or greater proportion of fetal urine than did the amniotic fluid during the study period. These results indicate the importance of the allantoic fluid volume and composition in the study of ovine fluid dynamics.
绵羊妊娠已被广泛研究，作为羊水代谢的模型，可能为人类羊水过少提供模型。然而，人们认识到，绵羊妊娠包含足月人类妊娠中不存在的尿囊液腔。早期对绵羊的研究表明，足月时胎儿尿液对尿囊液的贡献减少，但没有解释尿囊腔大量液体维持的原因。在本研究中，我们检测了近足月绵羊妊娠时3H-菊粉向尿囊腔和羊膜腔的相对胎儿尿排泄量。通过锝标记葡聚糖和铬标记红细胞稀释法测定的羊膜腔和尿囊腔体积相似，尽管成分存在显著差异。在研究期间，尿囊液腔比羊膜腔接受了相等或更大比例的胎儿尿液。这些结果表明尿囊液体积和成分在绵羊流体动力学研究中的重要性。
