Atlas Clinic, Batna, Algeria.
Service de rhumatologie institut M. T Kassab. UR17SP04 Faculté de médecine de Tunis, Université Tunis el Manar, Tunis, Tunisia.
Clin Rheumatol. 2021 Sep;40(9):3401-3410. doi: 10.1007/s10067-021-05630-w. Epub 2021 Feb 9.
Spondyloarthritis (SpA) has been less well studied than rheumatoid arthritis in North Africa, due to a belief that it is rare and benign in certain populations. The main genetic trait of SpA is its association with human leukocyte antigen (HLA)-B27. The distribution of this allele largely explains the prevalence and severity of SpA. The prevalence of HLA-B27 in the general population of North Africa is estimated at about 4%, and rises to about 60% among people affected with SpA. Coxitis is one of the main features of North African SpA, but the response to treatment is comparable to the literature from the West. The major challenge in North Africa remains accessibility to specialized care and means of early diagnosis. Prevalent infections in North Africa do not seem to be a major obstacle to optimal treatment strategies.
脊柱关节炎（SpA）在北非的研究不如类风湿关节炎多，这是因为人们认为它在某些人群中较为罕见且良性。SpA 的主要遗传特征与其与人类白细胞抗原（HLA）-B27 的关联有关。该等位基因的分布在很大程度上解释了 SpA 的流行和严重程度。北非普通人群中 HLA-B27 的流行率估计约为 4%，而在 SpA 患者中则上升至约 60%。髋关节炎是北非 SpA 的主要特征之一，但治疗反应与来自西方的文献相似。在北非，主要的挑战仍然是获得专业护理和早期诊断的途径。北非流行的感染似乎不是最佳治疗策略的主要障碍。
