Khan Muhammad A
Case Western Reserve University, Cleveland, OH, USA.
Curr Rheumatol Rep. 2017 Feb;19(2):9. doi: 10.1007/s11926-017-0640-1.
This publication updates an earlier review on the ever increasing knowledge about genetic polymorphism of HLA-B*27 and discusses its clinical relevance.
As of January 1, 2017, there are 213 known alleles of HLA-B27 at nucleotide sequence level, while at the translated protein level, there are 160 known subtypes based on one or more amino acid sequence differences. Some of these subtypes exhibit differential association with ankylosing spondylitis, and there may even be some level of hierarchy in this regard. On the other hand, HLA-B27 has a protective effect against HCV, and this effect is also influenced by some of the subtypes of HLA-B27. This may have important implications for designing anti-viral vaccines for global population and also for developing individualized treatments and vaccines. Disease association and disease protective roles of HLA-B27 suggest a common ground, i.e., promoting a more pronounced immune/inflammatory response for effective clearance of some pathogens, but that might, on the other hand, lead to autoimmunity and tissue injury in some circumstances.
本出版物更新了一篇关于对HLA - B*27基因多态性不断增长的认识的早期综述，并讨论了其临床相关性。
截至2017年1月1日，在核苷酸序列水平上，已知HLA - B27有213个等位基因，而在翻译后的蛋白质水平上，基于一个或多个氨基酸序列差异，已知有160个亚型。其中一些亚型与强直性脊柱炎的关联存在差异，在这方面甚至可能存在某种程度的层级关系。另一方面，HLA - B27对丙型肝炎病毒具有保护作用，并且这种作用也受到HLA - B27某些亚型的影响。这可能对为全球人群设计抗病毒疫苗以及开发个性化治疗方法和疫苗具有重要意义。HLA - B27的疾病关联和疾病保护作用表明存在一个共同点，即促进更明显的免疫/炎症反应以有效清除某些病原体，但另一方面，这在某些情况下可能导致自身免疫和组织损伤。
