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新冠病毒肺炎患者心脏成像的当代应用:一项三中心经验,确定心脏磁共振成像的潜在作用

Contemporary use of cardiac imaging for COVID-19 patients: a three center experience defining a potential role for cardiac MRI.

作者信息

Panchal Ankur, Kyvernitakis Andreas, Mikolich J Ronald, Biederman Robert W W

机构信息

Internal Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Cardiovascular Disease, Allegheny Health Network, Pittsburgh, PA, USA.

出版信息

Int J Cardiovasc Imaging. 2021 May;37(5):1721-1733. doi: 10.1007/s10554-020-02139-2. Epub 2021 Feb 9.

Abstract

The pandemic of coronavirus disease 2019 (COVID-19) secondary to the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has bestowed an unprecedented challenge upon us, resulting in an international public health emergency. COVID-19 has already resulted in > 1,600,000 deaths worldwide and the fear of a global economic collapse. SARS-CoV-2 is notorious for causing acute respiratory distress syndrome, however emerging literature suggests various dreaded cardiac manifestations associated with high mortality. The mechanism of myocardial damage in COVID-19 is unclear but thought to be multifactorial and mainly driven by the host's immune response (cytokine storm), hypoxemia and direct myocardial injury by the virus. Cardiac manifestations from COVID-19 include but are not limited to, acute myocardial injury, cardiac arrhythmias, congestive heart failure and acute coronary syndrome. Cardiac imaging is paramount to appropriately diagnose and manage the cardiac manifestations of COVID-19. Herein, we present cardiac imaging findings of COVID-19 patients with biomarker and imaging confirmed myocarditis to provide insight regarding the variable manifestations of COVID-19 myocarditis via Cardiac MRI (CMR) coupled with CMR-edema education along with recommendations on how to incorporate advanced CMR into the clinicians' COVID-19 armamentarium.

摘要

由新型严重急性呼吸综合征冠状病毒2(SARS-CoV-2)引发的2019冠状病毒病(COVID-19)大流行给我们带来了前所未有的挑战,导致了一场国际公共卫生紧急事件。COVID-19已在全球造成超过160万人死亡,并引发了对全球经济崩溃的担忧。SARS-CoV-2因可导致急性呼吸窘迫综合征而臭名昭著,然而,新出现的文献表明它还会引发各种可怕的心脏表现,且死亡率很高。COVID-19中心肌损伤的机制尚不清楚,但被认为是多因素的,主要由宿主的免疫反应(细胞因子风暴)、低氧血症和病毒直接导致的心肌损伤驱动。COVID-19的心脏表现包括但不限于急性心肌损伤、心律失常、充血性心力衰竭和急性冠状动脉综合征。心脏成像对于准确诊断和管理COVID-19的心脏表现至关重要。在此,我们展示了COVID-19患者的心脏成像结果,这些患者的生物标志物和成像结果证实患有心肌炎,以通过心脏磁共振成像(CMR)结合CMR水肿分析来深入了解COVID-19心肌炎的多样表现,并就如何将先进的CMR纳入临床医生应对COVID-19的手段提出建议。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8738/7871025/a086fbeb0ece/10554_2020_2139_Fig1_HTML.jpg

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