School of Chemistry, National University of Ireland Galway, University Road, Galway, H91 TK33, Ireland.
School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
Chemistry. 2021 Jun 10;27(33):8411-8436. doi: 10.1002/chem.202100093. Epub 2021 Mar 9.
The use of directing groups allows high levels of selectivity to be achieved in transition metal-catalyzed transformations. Efficient removal of these auxiliaries after successful functionalization, however, can be very challenging. This review provides a critical overview of strategies used for removal of Daugulis' 8-aminoquinoline (2005-2020), one of the most widely used N,N-bidentate directing groups. The limitations of these strategies are discussed and alternative approaches are suggested for challenging substrates. Our aim is to provide a comprehensive end-users' guide for chemists in academia and industry who want to harness the synthetic power of directing groups-and be able to remove them from their final products.
导向基团的使用可以在过渡金属催化转化中实现高水平的选择性。然而，在成功的功能化后，有效地去除这些助剂可能非常具有挑战性。这篇综述批判性地概述了用于去除道格拉斯（Daugulis）的 8-氨基喹啉（2005-2020）的策略，该试剂是最广泛使用的 N，N-双齿导向基团之一。讨论了这些策略的局限性，并为具有挑战性的底物提出了替代方法。我们的目的是为学术界和工业界的化学家提供全面的最终用户指南，他们希望利用导向基团的合成能力，并能够从最终产品中去除它们。
