Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, P. R. China.
Org Lett. 2021 Feb 19;23(4):1411-1415. doi: 10.1021/acs.orglett.1c00071. Epub 2021 Feb 9.
A benzene-free synthesis of multisubstituted catechol via an oxidative dearomatic reorganization is reported. This reaction tolerated a wide spectrum of functionalities, which could be applied in the synthesis of an electron-deficient arene-conjugated catechol that is difficult to access via biomimetic oxidative coupling. In addition, a diversification-oriented transformation that leveraged the versatile catechol afforded a series of functionality-rich products.
本文报道了一种通过氧化去芳构化实现多取代儿茶酚的无苯合成方法。该反应具有广泛的官能团容忍性，可用于合成难以通过仿生氧化偶联获得的缺电子芳烃共轭儿茶酚。此外，利用多功能儿茶酚的多样化转化方法得到了一系列富含官能团的产物。
