Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Sleep Breath. 2021 Dec;25(4):1753-1760. doi: 10.1007/s11325-021-02293-4. Epub 2021 Feb 9.
Obstructive sleep apnea (OSA) is a prevalent sleep disorder associated with increased risk of cardiovascular disease. Several studies have demonstrated elevated oxidative stress in patients with OSA. This oxidative stress is a direct inducer of lipid peroxidation. Malondialdehyde (MDA), a robust marker of lipid peroxidation, has been evaluated in patients with OSA but results have been inconsistent. The present systematic review and meta-analysis was performed to quantify the circulating levels of MDA in patients with OSA compared to controls.
Search was performed in data bases of PubMed, Scopus, EMBASE, Web of Science, and Cochrane library, to find out those studies that measured MDA in patients with OSA compared to controls.
The search produced 563 records and after removing duplicates, 383 records remained. Screening by title and abstract and the evaluation of the full text resulted in the selection of 14 articles, which were included in the meta-analysis. Pooled analysis demonstrated higher levels of MDA in the patients compared to the controls (SMD (95% CI): 1.18 (0.68, 1.68), p < 0.0001).
The results of this meta-analysis demonstrated considerable elevation of MDA in patients with OSA compared to controls. The meta-analysis also indicated a positive association of MDA levels with the degree of severity of OSA. These results suggest a state of increased lipid peroxidation in patients with OSA.
阻塞性睡眠呼吸暂停（OSA）是一种常见的睡眠障碍，与心血管疾病风险增加有关。多项研究表明，OSA 患者存在氧化应激升高。这种氧化应激是脂质过氧化的直接诱导剂。丙二醛（MDA）是脂质过氧化的一个强有力标志物，已经在 OSA 患者中进行了评估，但结果不一致。本系统评价和荟萃分析旨在定量比较 OSA 患者与对照组之间循环 MDA 水平。
在 PubMed、Scopus、EMBASE、Web of Science 和 Cochrane 图书馆数据库中进行检索，以找出那些比较 OSA 患者和对照组 MDA 测量的研究。
搜索产生了 563 条记录，去除重复后，剩余 383 条记录。通过标题和摘要筛选以及全文评估，选择了 14 篇文章进行荟萃分析。汇总分析显示，与对照组相比，患者的 MDA 水平更高（SMD（95%CI）：1.18（0.68，1.68），p<0.0001）。
荟萃分析的结果表明，与对照组相比，OSA 患者的 MDA 水平显著升高。荟萃分析还表明，MDA 水平与 OSA 严重程度呈正相关。这些结果表明 OSA 患者存在脂质过氧化增加的状态。
