Department of Otolaryngology, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, Fujian Province, People's Republic of China.
Department of Respiratory and Critical Care Medicine, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian Province, People's Republic of China.
Brain Behav. 2023 Apr;13(4):e2972. doi: 10.1002/brb3.2972. Epub 2023 Mar 20.
Alzheimer's disease (AD) is an irreversible, progressive brain disorder that impairs memory, thinking, language, and, eventually, the ability to carry out the simplest of tasks. Tau protein, the major component of neurofibrillary tangles, is considered a key mediator of AD pathogenesis. The association between obstructive sleep apnea (OSA) and circulating tau remains unclear. The aim of the present meta-analysis was to evaluate the relationship between OSA and circulating tau via quantitative analysis.
A systematic search of Pubmed, Embase, and Web of Science were performed. The mean values of circulating total tau (T-tau) and phosphorylated tau (P-tau) in OSA and control groups were extracted. Standardized mean difference (SMD) with 95% confidence interval (CI) was calculated by using a random-effect model or fixed-effect model.
A total of seven studies comprising 233 controls and 306 OSA patients were included in this study. The meta-analysis showed that the circulating T-tau level was significantly higher in OSA patients than those in the control group (SMD = 1.319, 95% CI = 0.594 to 2.044, z = 3.56, p < .001). OSA patients also had significantly higher circulating P-tau level than control group (SMD = 0.343, 95% CI = 0.122 to 0.564, z = 3.04, p = .002).
The present meta-analysis demonstrated that both circulating T-tau and P-tau levels were significantly increased in OSA subjects when compared with non-OSA subjects. Larger sample-size studies on the association between OSA and circulating tau are still required to further validate our results.
阿尔茨海默病（AD）是一种不可逆转的、进行性的大脑疾病，会损害记忆、思维、语言，最终导致无法完成最简单的任务。tau 蛋白是神经原纤维缠结的主要成分，被认为是 AD 发病机制的关键介质。阻塞性睡眠呼吸暂停（OSA）与循环 tau 之间的关联尚不清楚。本研究旨在通过定量分析评估 OSA 与循环 tau 之间的关系。
系统检索了 Pubmed、Embase 和 Web of Science。提取 OSA 组和对照组循环总 tau（T-tau）和磷酸化 tau（P-tau）的平均值。采用随机效应模型或固定效应模型计算标准化均数差值（SMD）及其 95%置信区间（CI）。
共有 7 项研究，包括 233 名对照者和 306 名 OSA 患者，纳入本研究。荟萃分析显示，OSA 患者的循环 T-tau 水平明显高于对照组（SMD=1.319，95%CI=0.594 至 2.044，z=3.56，p<0.001）。OSA 患者的循环 P-tau 水平也明显高于对照组（SMD=0.343，95%CI=0.122 至 0.564，z=3.04，p=0.002）。
本荟萃分析表明，与非 OSA 受试者相比，OSA 受试者的循环 T-tau 和 P-tau 水平均显著升高。仍需要更大样本量的研究来进一步验证我们的结果。
