Landes R R, Hall J W
Urology. 1977 Oct;10(4):312-6. doi: 10.1016/0090-4295(77)90157-1.
One hundred forty-six patients with recurrent urinary tract infections were treated with 500 mg. of cinoxacin twice daily for seven to fourteen days. Satisfactory clinical response occurred in 94 per cent. Of the 100 patients with significant pretherapy bacteriuria (greater than or equal to 10(4) organisms/ml. of urine), 65 had complicated infections. Approximately the same per cent of patients with (90 per cent) as without (94 per cent) complicating conditions had a satisfactory clinical response to treatment. The pathogen was eliminated in a higher percentage of patients without underlying disease (90 versus 80 per cent), and infections recurred less frequently in this group (3 versus 14 per cent). Emergence of resistance by initially susceptible organisms during the course of therapy occurred in 4 of 76 patients (5 per cent). A satisfactory clinical response occurred in all 46 patients with an initial colony count of less than 10(4) organisms/ml. urine. Only 1 patient in this group was a bacteriologic failure. Adverse effects of a relatively wild nature were seen in 4 of 146 patients (2.7 per cent). Successful eradication of 12 of 23 urinary infections in patients whose pathogens were resistant to the 30-microgram. cinoxacin disk suggests that the 100-microgram. disk may be more realistic for determining bacterial susceptibility by the disk diffusion method in view of the very high urinary concentration of the drug.
146例复发性尿路感染患者接受了每日两次、每次500毫克西诺沙星的治疗，疗程为7至14天。94%的患者取得了满意的临床疗效。在100例治疗前有显著菌尿（尿中细菌数大于或等于10⁴/ml）的患者中，65例患有复杂性感染。患有（90%）和未患有（94%）复杂情况的患者对治疗有满意临床疗效的比例大致相同。在无基础疾病的患者中，病原体清除率更高（90%对80%），且该组感染复发频率更低（3%对14%）。在76例患者中有4例（5%）在治疗过程中最初敏感的微生物出现了耐药。在初始菌落计数小于10⁴/ml尿液的所有46例患者中均取得了满意的临床疗效。该组中只有1例患者细菌学治疗失败。146例患者中有4例（2.7%）出现了性质相对严重的不良反应。在病原体对30微克西诺沙星纸片耐药的患者中，23例尿路感染有12例成功根除，这表明鉴于药物在尿液中的浓度非常高，100微克纸片对于通过纸片扩散法测定细菌敏感性可能更符合实际情况。
