Department of Hospital Pharmacy, Nagoya City University Graduate School of Pharmaceutical Sciences, Nagoya 467-8603, Japan.
Department of Clinical Pharmaceutics, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan.
Nutrients. 2021 Feb 7;13(2):539. doi: 10.3390/nu13020539.
High salt intake has been reported as a risk factor for urinary storage symptoms. However, the association between high salt intake and detrusor muscle contraction is not clear. Therefore, we investigated the effects of high salt intake on the components of detrusor muscle contraction in rats. Six-week-old male Dahl salt-resistant (DR; = 5) and Dahl salt-sensitive (DS; = 5) rats were fed a high salt (8% NaCl) diet for one week. The contractile responses of the detrusor muscle to the cumulative administration of carbachol and electrical field stimulation (EFS) with and without suramin and atropine were evaluated via isometric tension study. The concentration-response curves of carbachol were shifted more to the left in the DS group than those in the DR group. Contractile responses to EFS were more enhanced in the DS group than those in the DR group ( < 0.05). Cholinergic component-induced responses were more enhanced in the DS group than those in the DR group ( < 0.05). High salt intake might cause urinary storage symptoms via abnormalities in detrusor muscle contraction and the enhancement of cholinergic signals. Excessive salt intake should be avoided to preserve bladder function.
高盐摄入已被报道为尿储留症状的一个危险因素。然而，高盐摄入与逼尿肌收缩之间的关系尚不清楚。因此，我们研究了高盐摄入对大鼠逼尿肌收缩成分的影响。6 周龄雄性达尔盐抵抗（DR；n = 5）和达尔盐敏感（DS；n = 5）大鼠给予高盐（8% NaCl）饮食 1 周。通过等长张力研究评估了累积给予卡巴胆碱和电刺激（EFS）时以及加入苏拉明和阿托品前后逼尿肌的收缩反应。卡巴胆碱的浓度-反应曲线在 DS 组向左偏移程度大于 DR 组。EFS 引起的收缩反应在 DS 组比 DR 组更强（<0.05）。DS 组的胆碱能成分诱导的反应比 DR 组更强（<0.05）。高盐摄入可能通过逼尿肌收缩异常和胆碱能信号增强导致尿储留症状。为了保护膀胱功能，应避免摄入过多的盐。
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