Yamane N, Uemura H
Department of Laboratory Medicine, Kumamoto University Medical School, Japan.
Epidemiol Infect. 1988 Apr;100(2):291-9. doi: 10.1017/s095026880006742x.
The concentrations of serum IgE (PRIST) and IgE- and IgG-specific antibodies to egg protein were determined in paired sera taken from students who had received influenza virus vaccine. Although persons who gave a history of allergy to egg or to chicken feathers were excluded, 10-16% of vaccinees possessed higher titres of serum IgE and IgE-specific antibody (RAST) to egg white (F1) allergen before vaccination. The titres of IgG-specific antibody to egg protein (ovalbumin and ovomucoid antigens) were negligible, and did not show any significant response after vaccination. In contrast, IgE-specific antibody to F1 allergen rose significantly in a considerable number of the vaccines. The results obtained indicate possible contamination of vaccine products with allergens of egg origin and a potential risk of allergic manifestation after influenza vaccination.
对接受流感病毒疫苗接种的学生采集的配对血清进行检测，以测定血清IgE（PRIST法）以及针对鸡蛋蛋白的IgE和IgG特异性抗体的浓度。尽管有鸡蛋或鸡毛过敏史的人已被排除，但仍有10% - 16%的疫苗接种者在接种疫苗前血清IgE和针对蛋清（F1）过敏原的IgE特异性抗体（RAST法）滴度较高。针对鸡蛋蛋白（卵清蛋白和卵类粘蛋白抗原）的IgG特异性抗体滴度可忽略不计，接种疫苗后也未出现任何显著反应。相比之下，相当数量的接种者中针对F1过敏原的IgE特异性抗体显著升高。所得结果表明疫苗产品可能被鸡蛋来源的过敏原污染，流感疫苗接种后有发生过敏表现的潜在风险。
