Yamane N, Hiratsuka M, Arikawa J, Odagiri T, Ishida N
J Hyg (Lond). 1981 Dec;87(3):383-92. doi: 10.1017/s002217240006962x.
Antibody responses to influenza virus immunizations were examined among junior high school students. The students received two doses of a commercial split-product vaccine containing influenza A H1N1 during a 2-year period following the first appearance of H1N1 virus in the winter of 1977-78. In haemagglutination-inhibition (HI) tests, the students who had been infected with H1N1 virus in 1977-78 showed a better response and wider cross-reactivity to the drift strain than the students who had not experienced earlier H1N1 influenza infection. Neuraminidase-inhibition (NAI) antibody titres after immunization depended upon a history of natural infection with H1N1 virus, since students not previously infected showed no significant NAI antibody rise after immunization.
在初中生中检测了对流感病毒免疫接种的抗体反应。在1977 - 1978年冬季H1N1病毒首次出现后的两年期间，这些学生接种了两剂含甲型H1N1流感病毒的市售裂解疫苗。在血凝抑制（HI）试验中，1977 - 1978年感染过H1N1病毒的学生比未经历过早期H1N1流感感染的学生对变异株表现出更好的反应和更广泛的交叉反应性。免疫后的神经氨酸酶抑制（NAI）抗体滴度取决于H1N1病毒自然感染史，因为之前未感染的学生免疫后NAI抗体没有显著升高。
