Lauri D, Dejana E, Cortelazzo S, Orlando E, Zanetti A, Viero P, de Gaetano G, Barbui T
Vascular Physiopathology Unit, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.
Eur J Haematol. 1988 Mar;40(3):262-6. doi: 10.1111/j.1600-0609.1988.tb00834.x.
In this work we studied platelet adhesion to subendothelial surfaces in 10 patients with polycythaemia vera and 10 healthy volunteers at 40% Hct (corresponding to the mean value of our control group) and 55% Hct (a value roughly corresponding to the mean Hct in polycythaemic patients). Platelet concentration was kept constant at 2.0-2.5 X 10(11)/l. The results indicate that there was a statistically significant increase in adhesion both in controls and in patients with Hct varying from 40% to 55%. The contribution of the higher Hct in promoting platelet adhesion was comparable in the two groups. When red blood cells (RBC) from the patients were tested with platelets from healthy volunteers in cross-over experiments, they promoted adhesion in the same way as control RBC. Similarly, when patients' platelets were mixed with control RBC, adhesion was the same as control platelets. These data indicate that platelet and RBC contribution to this parameter are not significantly modified in this group of polycythaemic patients, provided that platelet and RBC values are adjusted to control range.
在这项研究中，我们对10名真性红细胞增多症患者和10名健康志愿者进行了研究，检测血细胞比容（Hct）为40%（对应于我们对照组的平均值）和55%（大致对应真性红细胞增多症患者的平均Hct值）时血小板与内皮下表面的黏附情况。血小板浓度保持在2.0 - 2.5×10¹¹/l不变。结果表明，在对照组和血细胞比容从40%变化到55%的患者中，黏附均有统计学上的显著增加。较高的血细胞比容在促进血小板黏附方面的作用在两组中相当。在交叉实验中，当用健康志愿者的血小板检测患者的红细胞（RBC）时，它们促进黏附的方式与对照红细胞相同。同样，当将患者的血小板与对照红细胞混合时，黏附情况与对照血小板相同。这些数据表明，在这组真性红细胞增多症患者中，只要血小板和红细胞值调整到对照范围，血小板和红细胞对该参数的作用不会有显著改变。
