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在 中工程化木糖代谢以生产有价值的化合物。

Engineering of xylose metabolism in for the production of valuable compounds.

机构信息

Environmental Waste Recycle Institute (EWRI), Department of Energy Science and Technology (DEST), Myongji University, Yongin, Gyeonggi, South Korea.

Division of Bioscience and Bioinformatics, Myongji University, Yongin, Gyeonggi, South Korea.

出版信息

Crit Rev Biotechnol. 2021 Aug;41(5):649-668. doi: 10.1080/07388551.2021.1873243. Epub 2021 Feb 9.

Abstract

The lignocellulosic sugar d-xylose has recently gained prominence as an inexpensive alternative substrate for the production of value-added compounds using genetically modified organisms. Among the prokaryotes, has become the host for the development of engineered microbial cell factories. The favored status of resulted from a century of scientific explorations leading to a deep understanding of its systems. However, there are limited literature reviews that discuss engineered as a platform for the conversion of d-xylose to any target compounds. Additionally, available critical review articles tend to focus on products rather than the host itself. This review aims to provide relevant and current information about significant advances in the metabolic engineering of d-xylose metabolism in . This focusses on unconventional and synthetic d-xylose metabolic pathways as several review articles have already discussed the engineering of native d-xylose metabolism. This paper, in particular, is essential to those who are working on engineering of d-xylose metabolism using as the host.

摘要

木质纤维素糖 d-木糖最近作为一种廉价的替代底物,通过基因修饰的生物体来生产有价值的化合物而备受关注。在原核生物中, 已成为工程微生物细胞工厂的首选宿主。 之所以受到青睐,是因为一个世纪以来的科学探索使其对其系统有了深入的了解。然而,关于将 d-木糖转化为任何目标化合物的工程 作为平台的讨论,相关文献综述却很有限。此外,现有的评论文章往往侧重于产品,而不是宿主本身。这篇综述旨在提供关于 在 中代谢工程 d-木糖代谢方面的重要进展的相关和最新信息。这主要集中在非传统和合成的 d-木糖代谢途径上,因为已经有几篇综述文章讨论了天然 d-木糖代谢的工程改造。对于那些使用 作为宿主进行 d-木糖代谢工程的人来说,这篇论文尤其重要。

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