Division of Infectious Diseases, Department of Pediatrics, Hospital Universitario "Dr. José Eleuterio González", Monterrey, México.
Department of Microbiology, Facultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey, Mexico.
J Chemother. 2021 Dec;33(8):519-527. doi: 10.1080/1120009X.2020.1867946. Epub 2021 Feb 10.
In the era of antifungal prophylaxis for cancer patients, genus has become the second leading cause of invasive fungal infections and mortality in this group of patients. The intrinsic resistance to antifungal agents and the patient's risk factors are the most important variables for prognosis and survival. Currently, the use of monotherapy in comparison to combined antifungal treatment information is scarce. In this report, we present a series of three cases of children with acute lymphoblastic leukemia and disseminated fusariosis categorized according to the European Organization for Research and Treatment of Cancer/Mycoses Study Group (EORTC/MSG). Furthermore, we present a current literature review focused on treatment using monotherapy or combined antifungal treatment.
在癌症患者抗真菌预防的时代，镰孢菌属已成为该人群中侵袭性真菌感染和死亡率的第二大主要原因。对抗真菌药物的固有耐药性和患者的危险因素是预后和生存的最重要变量。目前，与联合抗真菌治疗信息相比，单药治疗的使用信息较少。在本报告中，我们根据欧洲癌症研究与治疗组织/霉菌病研究组（EORTC/MSG）的分类，报告了三例急性淋巴细胞白血病和播散性镰刀菌病儿童的病例系列。此外，我们还进行了一项当前文献综述，重点关注使用单药治疗或联合抗真菌治疗。
