Department of Dermatology, St George's University Hospitals NHS Foundation Trust, London, UK.
UK National Mycology Reference Laboratory, UK Health Security Agency (UKHSA), Bristol, UK.
Pediatr Dermatol. 2023 May-Jun;40(3):503-506. doi: 10.1111/pde.15179. Epub 2022 Nov 5.
Fusarium is a polyphyletic genus of plant pathogens, members of which can cause opportunistic human infections with varying superficial and systemic presentations, including disseminated infections which typically occur in immunocompromised patients and have a poor prognosis. Treatment is challenging due to intrinsic resistance to many antifungal agents, and antifungal susceptibility testing is therefore essential. Early suspicion, isolation of the organism, and prompt initiation of management are crucial to improving survival. We present a case of disseminated Bisifusarium infection following toxic epidermal necrolysis in a child with B-cell acute lymphoblastic leukemia, successfully treated with liposomal amphotericin B, voriconazole, flucytosine, and terbinafine.
镰刀菌是一类植物病原体的多系属，其成员可导致表现形式不同的机会性人类感染，包括播散性感染，此类感染通常发生在免疫功能低下的患者中，预后较差。由于对许多抗真菌药物具有内在耐药性，因此治疗具有挑战性，因此抗真菌药敏试验至关重要。早期怀疑、病原体分离以及及时开始治疗对于提高生存率至关重要。我们报告了一例患有 B 细胞急性淋巴细胞白血病的儿童在发生中毒性表皮坏死松解症后发生播散性双曲霉菌感染的病例，该病例成功地接受了脂质体两性霉素 B、伏立康唑、氟胞嘧啶和特比萘芬治疗。
