1st Department of Urology, Aristotle University of Thessaloniki, "G. Gennimatas" General Hospital, Thessaloniki, Greece.
Department of Surgery, Division of Urology, Tottori University Faculty of Medicine, Yonago, Japan.
Curr Pharm Des. 2021;27(24):2796-2801. doi: 10.2174/1381612827666210204160248.
BACKGROUND & OBJECTIVE: Significant advances in the field of male infertility have been witnessed during the last years. Given the well-known detrimental effects of reactive oxygen species (ROS), the administration of antioxidants has emerged as a promising solution for oxidative stress (OS)-induced male infertility. Nevertheless, this perception seems largely oversimplified, and the existing literature fails to recognize a notable superiority of the excessive use of these widely available nutritional compounds. Taking into consideration that several trials have shed light on the so-called "antioxidant paradox" phenomenon, we recognize that over-the-counter consumption of such supplements might be harmful.
The relevant studies indexed in PubMed, Google Scholar and Scopus databases, published until September 2019 were identified and reported.
In this setting, we acknowledge that there is an urgent need for more elaborate studies in the future that will efficiently elucidate the risks and benefits of antioxidants on semen parameters and their impact on fertility potential.
近年来，男性不育领域取得了重大进展。鉴于活性氧（ROS）的已知有害影响，抗氧化剂的应用已成为治疗氧化应激（OS）引起的男性不育的一种有前途的方法。然而，这种观点似乎过于简单化，并且现有文献未能认识到过度使用这些广泛可用的营养化合物的显著优势。考虑到几项试验揭示了所谓的“抗氧化剂悖论”现象，我们认识到，过量服用这些补充剂可能是有害的。
检索 PubMed、Google Scholar 和 Scopus 数据库中截至 2019 年 9 月发表的相关研究，并进行报告。
在这种情况下，我们认识到未来迫切需要更精细的研究，以有效地阐明抗氧化剂对精液参数的风险和益处及其对生育潜力的影响。
