Faculty of Science and Natural Resources, University Malaysia Sabah, Jalan UMS, 88400, Kota Kinabalu, Sabah,Malaysia.
Curr Pharm Biotechnol. 2022;23(1):47-59. doi: 10.2174/1389201022666210208201212.
Underutilized plants are referred to a plant species whose potential is not fully utilized yet and they are usually found abundantly in certain local areas but are globally rare. Sabah is known for high biodiversity and contains many underutilized plants. To our knowledge, this is the first review to provide overview information of the medicinal value and pharmacological properties of underutilized plants in Sabah. Extract and metabolites in different parts of several underutilized plants contain multiple beneficial bioactive compounds and the exploitation of these compounds was supported by additional data that plays various biological activities, including anti-atherosclerotic, anti-cancer antihypercholesterolemic and anti-ulcerogenic. A handful of pharmacological studies on these underutilized plants have conclusively outlined the mode of action in treatment of several diseases and in other health aspects. This paper limits its scope to review and highlight the potential of using underutilized plants in Sabah only which could serve as reliable resource for health product development in pharmaceutical and nutraceutical through continuous discovering of more active and sustainable resources as well as ingredients for food and medicine.
未充分利用的植物是指那些其潜力尚未得到充分利用的植物物种,它们通常在某些特定地区大量存在,但在全球范围内却很罕见。沙巴州以生物多样性高而闻名,拥有许多未充分利用的植物。据我们所知,这是第一篇综述介绍沙巴州未充分利用植物的药用价值和药理学特性的综述。几种未充分利用植物的不同部位的提取物和代谢物含有多种有益的生物活性化合物,这些化合物的开发得到了额外数据的支持,这些数据具有多种生物活性,包括抗动脉粥样硬化、抗癌、降胆固醇和抗溃疡。少数关于这些未充分利用植物的药理学研究已经明确概述了它们在治疗多种疾病和其他健康方面的作用机制。本文的范围仅限于综述和强调在沙巴州利用未充分利用植物的潜力,这可以作为药物和营养保健品开发健康产品的可靠资源,通过不断发现更具活性和可持续性的资源以及食品和药品的成分。