Independent Researcher, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh- 462020, India.
Department of Biochemistry, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh- 462020, India.
Curr Stem Cell Res Ther. 2021;16(8):970-979. doi: 10.2174/1574888X16666210203105800.
Recent evidence confirms that not each tumor cell is proficient in instigating a tumor. Merely a small part of the cancer cells, so-called cancer stem cells (CSCs), can produce cancer indistinguishable from the first one. CSC model has been recognized as a cellular component that adds to phenotypic and functional heterogeneity in different cancers. The latest explanations have featured numerous complexities and difficulties like CSC phenotype that can differ extensively between patients. Tumors may harbor various phenotypically or genetically specific CSCs, and consequently, metastatic CSCs can develop from vital CSCs and tumor cells. Scientists have discovered a few markers for CSCs. The recent finding reveals that CSCs are resistant to radiotherapy and chemotherapy and may clarify the disease's reappearance. Minimal amounts of CSCs can repopulate a tumor. Subsequently, it is essential to understand the attributes and mechanisms by which CSCs show their resistance to therapeutic agents. These aptitudes contribute to new bits of knowledge that give better therapeutic motivations to discover novel anticancer therapeutics. Accordingly, remedial procedures that emphasize focusing on CSCs and their microenvironmental niche are insufficient for conventional malignant growth treatments to eradicate the CSCs that, in any case, bring about therapy resistance. Mutual utilization of traditional therapies with CSC- specific agents may offer a promising technique for enduring cancer treatment as well as remedy.
最近的证据证实，并非每个肿瘤细胞都能有效地引发肿瘤。只有一小部分癌细胞，即所谓的癌症干细胞 (CSC)，能够产生与最初肿瘤无异的癌症。CSC 模型已被认为是导致不同癌症表型和功能异质性的细胞成分之一。最新的解释强调了许多复杂性和困难，例如 CSC 表型在患者之间可能存在广泛差异。肿瘤可能含有各种表型或遗传特异性的 CSC，因此，转移性 CSC 可能从重要的 CSC 和肿瘤细胞中发展而来。科学家们已经发现了一些 CSC 的标记物。最近的发现表明，CSC 对放疗和化疗具有抵抗力，这可能解释了疾病的复发。少量的 CSC 就可以重新填充肿瘤。因此，了解 CSC 抵抗治疗药物的特性和机制至关重要。这些特性为新的知识提供了依据，为发现新的抗癌治疗方法提供了更好的治疗动机。因此，强调针对 CSC 及其微环境龛的治疗方法对于传统的恶性肿瘤治疗不足以根除 CSC，而 CSC 仍然会导致治疗耐药性。传统疗法与 CSC 特异性药物的联合应用可能为持久的癌症治疗和治疗提供一种有前途的技术。
