Centre for Occupational and Environmental Health, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Centre for Occupational and Environmental Health, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK
Occup Environ Med. 2021 Apr;78(4):293-295. doi: 10.1136/oemed-2020-106881. Epub 2021 Feb 9.
Exposure to cleaning and disinfection products has been associated with respiratory disorders such as asthma in cleaning and healthcare workers. Safety data sheets (SDSs) provide information on hazardous chemicals that are present in products to help users with risk assessment and implement appropriate control measures. However, they have potential limitations in identifying respiratory hazards due to a lack of regulatory test methods for respiratory sensitisation and irritation of chemicals.
SDSs were first used to identify chemicals on the database as respiratory sensitisers and irritants. A quantitative structure-activity relationship (QSAR) model and an asthmagen list established by the Association of Occupational and Environmental Clinics (AOEC) were used to identify potential respiratory sensitisers and irritants (by the AOEC list only) in the cleaning and disinfection products.
From a total of 459 cleaning and disinfection products used in healthcare organisations across England and Wales, 35 respiratory sensitisers not labelled as such on the SDS were identified by QSAR or AOEC. Only 2% of cleaning and disinfection products contained at least one respiratory sensitiser as identified by their SDSs; this was increased to 37.7% of products when the QSAR or the AOEC list was used.
A significantly higher proportion of cleaning products contain respiratory hazardous chemicals, particularly respiratory sensitisers than would be expected from the information provided by SDSs alone. Cleaners and healthcare workers may, therefore, be insufficiently protected.
清洁和消毒产品的暴露与清洁和医护人员的哮喘等呼吸道疾病有关。安全数据表 (SDS) 提供了产品中存在的危险化学品的信息,以帮助用户进行风险评估并实施适当的控制措施。然而,由于缺乏针对化学品呼吸致敏和刺激性的监管测试方法,它们在识别呼吸危害方面存在潜在的局限性。
首先使用 SDS 在数据库中识别出作为呼吸敏化剂和刺激性的化学品。定量构效关系 (QSAR) 模型和职业与环境诊所协会 (AOEC) 建立的哮喘原清单用于识别清洁和消毒产品中的潜在呼吸敏化剂和刺激性物质(仅由 AOEC 清单识别)。
在英格兰和威尔士的医疗机构中使用的 459 种清洁和消毒产品中,有 35 种呼吸敏化剂未在 SDS 上标记为此类物质。只有 2%的清洁和消毒产品含有 SDS 确定的至少一种呼吸敏化剂;当使用 QSAR 或 AOEC 清单时,产品的这一比例增加到 37.7%。
与 SDS 单独提供的信息相比,含有呼吸危害化学物质的清洁产品,尤其是呼吸敏化剂的比例显著更高。因此,清洁剂和医护人员可能没有得到充分保护。