行造血干细胞动员治疗的患者中出现耐甲氧西林金黄色葡萄球菌（MRSA）性脂膜炎。

Methicillin-resistant (MRSA) panniculitis in a patient undergoing stem cell mobilisation.

机构信息

Department of Internal Medicine, National University Health System, Singapore

Department of Haematology, National University Cancer Institute Singapore, National University Health System, Singapore.

出版信息

BMJ Case Rep. 2021 Feb 9;14(2):e236382. doi: 10.1136/bcr-2020-236382.

DOI:10.1136/bcr-2020-236382

PMID:33563686

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7875283/

Abstract

Methicillin-resistant (MRSA) can cause a wide range of skin infections, however MRSA panniculitis without bacteremia is a rare manifestation. Here, we report a woman in her 20s with relapsed Hodgkin lymphoma undergoing stem cell mobilisation who presented with bilateral subcutaneous nodules over her shins. Ultrasound scan of one nodule showed non-specific inflammatory changes. Punch biopsy of a nodule showed lobular panniculitis with Gram-positive cocci. Blood cultures were negative but a culture from the biopsy grew MRSA. She was started on doxycycline with improvement in her symptoms. This case serves as a reminder to consider infections as a cause of panniculitis in immunocompromised patients.

摘要

耐甲氧西林金黄色葡萄球菌（MRSA）可引起广泛的皮肤感染，但无菌血症的 MRSA 脂膜炎是一种罕见的表现。在此，我们报告一例 20 多岁的复发霍奇金淋巴瘤患者在进行干细胞动员时出现双侧小腿皮下结节。一个结节的超声检查显示非特异性炎症改变。一个结节的活检显示小叶性脂膜炎伴革兰阳性球菌。血培养阴性，但活检培养出耐甲氧西林金黄色葡萄球菌。她开始服用多西环素，症状改善。这个病例提醒我们，在免疫功能低下的患者中，应考虑感染是脂膜炎的病因之一。