The Complex Dynamics of Hepatitis B Infected Individuals with Optimal Control.

This paper proposes various stages of the hepatitis B virus (HBV) besides its transmissibility and nonlinear incidence rate to develop an epidemic model. The authors plan the model, and then prove some basic results for the well-posedness in term of boundedness and positivity. Moreover, the authors find the threshold parameter , called the basic/effective reproductive number and carry out local sensitive analysis. Furthermore, the authors examine stability and hence condition for stability in terms of . By using sensitivity analysis, the authors formulate a control problem in order to eradicate HBV from the population and proved that the control problem actually exists. The complete characterization of the optimum system was achieved by using the 4-order Runge-Kutta procedure.