Bioinformatics Group, Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK.
Lipidomics facility, Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK.
F1000Res. 2021 Jan 6;10:4. doi: 10.12688/f1000research.28022.2. eCollection 2021.
Lipidomics increasingly describes the quantification using mass spectrometry of all lipids present in a biological sample. As the power of lipidomics protocols increase, thousands of lipid molecular species from multiple categories can now be profiled in a single experiment. Observed changes due to biological differences often encompass large numbers of structurally-related lipids, with these being regulated by enzymes from well-known metabolic pathways. As lipidomics datasets increase in complexity, the interpretation of their results becomes more challenging. BioPAN addresses this by enabling the researcher to visualise quantitative lipidomics data in the context of known biosynthetic pathways. BioPAN provides a list of genes, which could be involved in the activation or suppression of enzymes catalysing lipid metabolism in mammalian tissues.
脂质组学越来越多地描述了使用质谱技术对生物样本中存在的所有脂质进行定量分析。随着脂质组学方法的不断发展，现在可以在单次实验中对来自多个类别的数千种脂质分子进行分析。由于生物学差异而观察到的变化通常包含大量结构相关的脂质，这些脂质受到来自知名代谢途径的酶的调节。随着脂质组学数据集变得越来越复杂，其结果的解释变得更加具有挑战性。BioPAN 通过使研究人员能够在已知生物合成途径的背景下可视化定量脂质组学数据来解决这个问题。BioPAN 提供了一份可能参与激活或抑制催化哺乳动物组织中脂质代谢的酶的基因列表。
