Jalalzadeh Mojgan, Valencia-Manrique Julio C, Boma Noella, Chaudhari Ashok, Chaudhari Shobhana
Internal Medicine/Nephrology, Metropolitan Hospital Center, New York Medical College, New York, USA.
Internal Medicine, Metropolitan Hospital Center, New York Medical College, New York, USA.
Cureus. 2021 Jan 4;13(1):e12485. doi: 10.7759/cureus.12485.
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a rare occurrence in systemic sclerosis (SSc) patients. AAV is an inflammatory disease that can lead to kidney failure due to the infiltration of mononuclear cells and the destruction of blood vessels. Also, crescentic glomerulonephritis (GN) has rarely been reported with coronavirus disease 2019 (COVID-19) and acute tubular injury is the most common renal pathology lesion in these patients. We present a rare case of a 46-year-old woman with SSc with new onset of renal failure after a recent diagnosis of COVID-19. Her serology was positive for p-ANCA and myeloperoxidase antibodies. Kidney biopsy was done and showed crescentic GN. We suggest during this pandemic, patients with an immunological disorder that are infected with COVID-19 be closely monitored for any organ involvement.
抗中性粒细胞胞浆抗体（ANCA）相关性血管炎（AAV）在系统性硬化症（SSc）患者中较为罕见。AAV是一种炎症性疾病，可因单核细胞浸润和血管破坏导致肾衰竭。此外，2019冠状病毒病（COVID-19）患者中很少有新月形肾小球肾炎（GN）的报道，急性肾小管损伤是这些患者最常见的肾脏病理病变。我们报告了一例罕见病例，一名46岁的SSc女性在最近诊断出COVID-19后出现了新发肾衰竭。她的血清学检查显示p-ANCA和髓过氧化物酶抗体呈阳性。进行了肾脏活检，结果显示为新月形GN。我们建议在此次大流行期间，对感染COVID-19的免疫功能紊乱患者密切监测是否有任何器官受累情况。
