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合成代谢雄激素类固醇与心脏代谢紊乱

Anabolic-Androgenic Steroids and Cardiometabolic Derangements.

作者信息

Farzam Khashayar

机构信息

Family Medicine, University of Iowa Hospitals and Clinics, Iowa City, USA.

出版信息

Cureus. 2021 Jan 5;13(1):e12492. doi: 10.7759/cureus.12492.

DOI:10.7759/cureus.12492
PMID:33564503
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7861066/
Abstract

Anabolic-androgenic steroids (AAS) are commonly used among both competitive athletes and recreational athletes in order to gain a performance edge. Unfortunately, AAS generally carries a broad range of short term and long term adverse effects. These include endocrinological abnormalities, cardiovascular risks, psychological issues, and largely adverse effects on every organ system in the human body. While testosterone, and at times oxandrolone, are used for clinical purposes, AAS generally encompasses a very broad range of synthetic compounds that are used at high doses. In this case report, we look at a patient who has used the vast majority of common anabolic steroids over the past three decades and how these compounds may affect long-term metabolic and cardiovascular health. The purpose is to provide a primary care approach to this patient population.

摘要

合成代谢雄激素类固醇(AAS)在竞技运动员和业余运动员中都普遍使用,以获取成绩优势。不幸的是,AAS通常会带来广泛的短期和长期不良影响。这些影响包括内分泌异常、心血管风险、心理问题,以及对人体每个器官系统的重大不良影响。虽然睾酮,有时还有氧雄龙,用于临床目的,但AAS通常涵盖大量高剂量使用的合成化合物。在本病例报告中,我们观察了一名在过去三十年中使用了绝大多数常见合成代谢类固醇的患者,以及这些化合物如何影响长期代谢和心血管健康。目的是为这一患者群体提供一种初级保健方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0f1/7861066/a24be83011fa/cureus-0013-00000012492-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0f1/7861066/a24be83011fa/cureus-0013-00000012492-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0f1/7861066/a24be83011fa/cureus-0013-00000012492-i01.jpg

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本文引用的文献

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Sudden Cardiac Death in Anabolic-Androgenic Steroid Users: A Literature Review.《使用合成代谢-雄性激素类固醇者的心脏性猝死:文献综述》
Medicina (Kaunas). 2020 Nov 4;56(11):587. doi: 10.3390/medicina56110587.
2
Cardiorespiratory fitness, muscular strength and risk of type 2 diabetes: a systematic review and meta-analysis.心肺健康、肌肉力量与 2 型糖尿病风险:系统评价和荟萃分析。
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提高成绩药物对健康的不良后果:美国内分泌学会科学声明
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The history of synthetic testosterone.合成睾酮的历史。
Sci Am. 1995 Feb;272(2):76-81. doi: 10.1038/scientificamerican0295-76.