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化脓性肉芽肿的一种罕见表现。

An Uncommon Presentation of Pyogenic Granuloma.

作者信息

Luna-Ceron Eder, Gómez-Gutiérrez Ana K, Gonzalez-Hernandez Cinthia, Gatica-Torres Michelle

机构信息

Clinical Sciences, Tecnológico de Monterrey, Mexico City, MEX.

Family and Community Medicine, Centro de Salud con Servicios Ampliados, Anáhuac, MEX.

出版信息

Cureus. 2021 Jan 5;13(1):e12509. doi: 10.7759/cureus.12509.

DOI:10.7759/cureus.12509
PMID:33564515
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7861056/
Abstract

Benign vascular neoplasms are common clinical problems encountered in the practice of primary care. Pyogenic granulomas are one of the most common benign vascular lesions in young adults. Although the physiopathological mechanism for the development of this condition is still not well understood, it has been commonly associated with several triggers such as treatment with retinoids, biological agents, invasive cutaneous therapies and trauma. The development of pyogenic granulomas on sites of vascular malformations like port wine stains has been described in the literature to occur rarely. Most of these types of cases have been studied to occur in the setting of pregnancy and after cryotherapy or pulsated laser therapy. The aim of this article is to present the case of a 21-year-old man with a recent appearance of a pyogenic granuloma within an underlying port wine stain in the posterior cervical region without any history of triggers or risk factors. Excision of the vascular lesion was done, and histopathological report confirmed the diagnosis. The objective of this manuscript is to discuss the possible mechanisms involved in the development of this uncommon presentation and to summarize the current literature related to this clinical scenario.

摘要

良性血管肿瘤是基层医疗实践中常见的临床问题。化脓性肉芽肿是年轻成年人中最常见的良性血管病变之一。尽管这种疾病发生发展的生理病理机制仍未完全明确,但通常与多种诱因有关,如使用维甲酸、生物制剂、侵入性皮肤治疗和创伤等。文献中曾报道,在葡萄酒色斑等血管畸形部位很少出现化脓性肉芽肿。大多数此类病例是在妊娠期间以及冷冻疗法或脉冲激光治疗后发生的。本文旨在介绍一名21岁男性的病例,该患者在颈后区潜在的葡萄酒色斑内近期出现了化脓性肉芽肿,且无任何诱因或危险因素史。对该血管病变进行了切除,组织病理学报告证实了诊断。本文的目的是探讨这种罕见表现发生发展的可能机制,并总结与该临床情况相关的现有文献。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df4f/7861056/9504f72df052/cureus-0013-00000012509-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df4f/7861056/7f9528b3161a/cureus-0013-00000012509-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df4f/7861056/9504f72df052/cureus-0013-00000012509-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df4f/7861056/7f9528b3161a/cureus-0013-00000012509-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df4f/7861056/9504f72df052/cureus-0013-00000012509-i02.jpg

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1
An Uncommon Presentation of Pyogenic Granuloma.化脓性肉芽肿的一种罕见表现。
Cureus. 2021 Jan 5;13(1):e12509. doi: 10.7759/cureus.12509.
2
Pyogenic granuloma arising within a port-wine stain.葡萄酒色斑内发生的化脓性肉芽肿。
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Acta Chir Plast. 2003;45(2):52-4.
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Pyogenic granuloma arising in port-wine stain after cryotherapy.冷冻治疗后葡萄酒色斑中出现的化脓性肉芽肿。
Dermatol Online J. 2003 Dec;9(5):16.
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Pyogenic granuloma (lobular capillary hemangioma) within port-wine stains.葡萄酒色斑内的化脓性肉芽肿(小叶性毛细血管瘤)。
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Laser applications for benign oral lesions.激光在口腔良性病变中的应用。
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Pyogenic granuloma, port-wine stain and pregnancy.化脓性肉芽肿、葡萄酒色斑和妊娠。
Australas J Dermatol. 2011 Nov;52(4):e8-e10. doi: 10.1111/j.1440-0960.2010.00680.x. Epub 2010 Aug 16.
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[Fegelers syndrome, acquired port-wine stain or acquired capillary malformation: three cases and a literature review].[费格勒氏综合征、后天性葡萄酒色斑或后天性毛细血管畸形:三例病例及文献综述]
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引用本文的文献

1
Concurrent Occurrence of Lobular Capillary Haemangioma and Port-Wine Stain: A Case Report and Literature Review.小叶状毛细血管瘤与葡萄酒色斑并发:一例报告及文献复习
Cureus. 2023 May 6;15(5):e38642. doi: 10.7759/cureus.38642. eCollection 2023 May.

本文引用的文献

1
The Pathogenesis of Port Wine Stain and Sturge Weber Syndrome: Complex Interactions between Genetic Alterations and Aberrant MAPK and PI3K Activation.葡萄酒色斑和脑面血管瘤病的发病机制:遗传改变与异常 MAPK 和 PI3K 激活之间的复杂相互作用。
Int J Mol Sci. 2019 May 7;20(9):2243. doi: 10.3390/ijms20092243.
2
Pyogenic granuloma over the venous component of a mixed vascular malformation.混合性血管畸形静脉成分上的化脓性肉芽肿。
J Cutan Pathol. 2019 May;46(5):368-371. doi: 10.1111/cup.13429. Epub 2019 Feb 7.
3
Pyogenic Granuloma - A Common Benign Vascular Tumor with Variable Clinical Presentation: New Findings and Treatment Options.
化脓性肉芽肿——一种临床表现多样的常见良性血管肿瘤:新发现与治疗选择
Open Access Maced J Med Sci. 2017 Jul 13;5(4):423-426. doi: 10.3889/oamjms.2017.111. eCollection 2017 Jul 25.
4
BRAF and RAS Mutations in Sporadic and Secondary Pyogenic Granuloma.散发性和继发性脓性肉芽肿中的 BRAF 和 RAS 突变。
J Invest Dermatol. 2016 Feb;136(2):481-6. doi: 10.1038/JID.2015.376.
5
Pyogenic granuloma, an impaired wound healing process, linked to vascular growth driven by FLT4 and the nitric oxide pathway.化脓性肉芽肿,一种受损的伤口愈合过程,与由 FLT4 和一氧化氮通路驱动的血管生长有关。
Mod Pathol. 2013 Feb;26(2):247-55. doi: 10.1038/modpathol.2012.148. Epub 2012 Sep 7.
6
Oral pyogenic granuloma: Various concepts of etiopathogenesis.口腔化脓性肉芽肿:病因发病机制的多种概念。
J Oral Maxillofac Pathol. 2012 Jan;16(1):79-82. doi: 10.4103/0973-029X.92978.
7
Pyogenic granuloma, port-wine stain and pregnancy.化脓性肉芽肿、葡萄酒色斑和妊娠。
Australas J Dermatol. 2011 Nov;52(4):e8-e10. doi: 10.1111/j.1440-0960.2010.00680.x. Epub 2010 Aug 16.
8
Treatment options for cutaneous pyogenic granulomas: a review.皮肤化脓性肉芽肿的治疗选择:综述。
J Plast Reconstr Aesthet Surg. 2011 Sep;64(9):1216-20. doi: 10.1016/j.bjps.2010.12.021. Epub 2011 Feb 11.
9
Vascular anomalies: portwine stains and hemangiomas.血管异常:葡萄酒色斑和血管瘤。
J Cutan Pathol. 2010 Apr;37 Suppl 1:88-95. doi: 10.1111/j.1600-0560.2010.01519.x.
10
Pyogenic granuloma arising within a port-wine stain.葡萄酒色斑内发生的化脓性肉芽肿。
Cutis. 2004 Mar;73(3):175-80.