Taheri H, Tavakoli M B
MSc, Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
PhD, Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
J Biomed Phys Eng. 2021 Feb 1;11(1):39-46. doi: 10.31661/jbpe.v0i0.889. eCollection 2021 Feb.
Some brain tumors such as ependymoma and Medulloblastoma have similar MR images which may result to undifferentiated them from each other.
This study aimed to compare the apparent diffusion coefficient (ADC) of two different cerebellar pediatric tumors, including ependymoma and medulloblastoma which have shown similar clinical images in conventional magnetic resonance imaging (MRI) methods.
In this analytical study, thirty six pediatric patients who were suspected to have the mentioned tumors according to their CT image findings were included in this study. The patients were subjected to conventional MRI protocols followed by diffusion weighted imaging (DWI) and ADC values of the tumors were calculated automatically using MRI scanner software.
The mean (± SD) ADC value for ependymoma (1.2± 0.06 ×10 mm/s) was significantly higher than medulloblastoma (0.87 ± 0.02 ×10 mm/s) (p = 0.041). Moreover, the maximum ADC value of ependymoma was considerably different in comparison with medulloblastoma (1.4 ×10 mm/s and 0.96×10 mm/s, respectively; p = 0.035). Furthermore, the minimum ADC value of ependymoma was higher compared to medulloblastoma (1.0 ×10 mm/s and 0.61×10 mm/s, respectively), but there was not significant (p = 0.067).
Evaluation of ADC values for ependymoma and medulloblastoma is a reliable method to differentiate these two malignancies. This is due to different ADC values reflected during the evaluation.
一些脑肿瘤，如室管膜瘤和髓母细胞瘤，具有相似的磁共振成像（MR）图像，这可能导致它们彼此难以区分。
本研究旨在比较两种不同的小儿小脑肿瘤的表观扩散系数（ADC），这两种肿瘤为室管膜瘤和髓母细胞瘤，它们在传统磁共振成像（MRI）方法中表现出相似的临床图像。
在这项分析研究中，纳入了36例根据CT图像结果怀疑患有上述肿瘤的小儿患者。患者接受传统MRI检查，随后进行扩散加权成像（DWI），并使用MRI扫描仪软件自动计算肿瘤的ADC值。
室管膜瘤的平均（±标准差）ADC值（1.2±0.06×10⁻³mm²/s）显著高于髓母细胞瘤（0.87±0.02×10⁻³mm²/s）（p = 0.041）。此外，室管膜瘤的最大ADC值与髓母细胞瘤相比有显著差异（分别为1.4×10⁻³mm²/s和0.96×10⁻³mm²/s；p = 0.035）。此外，室管膜瘤的最小ADC值高于髓母细胞瘤（分别为1.0×10⁻³mm²/s和0.61×10⁻³mm²/s），但差异不显著（p = 0.067）。
评估室管膜瘤和髓母细胞瘤的ADC值是区分这两种恶性肿瘤的可靠方法。这是由于评估过程中反映出的ADC值不同。
