The Association Between Area Deprivation Index and Patient-Reported Outcomes in Patients with Advanced Cancer.

This analysis describes associations between area deprivation and patient-reported outcomes among patients with advanced cancer. This is a cross-sectional analysis of baseline data from a multisite primary palliative care intervention trial. Participants were adult patients with advanced cancer. Patient-level area deprivation scores were calculated using the Area Deprivation Index (ADI). Quality of life and symptom burden were measured. Uni- and multivariate regressions estimated associations between area deprivation and outcomes of interest. Among 672 patients, ∼0.5 (54%) were women and most (94%) were Caucasian. Mean age was 69.3±10.2 years. Lung (36%), breast (13%), and colon (10%) were the most common malignancies. Mean ADI was 64.0, scale of 1 (low)-100 (high). In unadjusted univariate analysis, Functional Assessment of Cancer Therapy-Palliative (=0.002), Edmonton Symptom Assessment Scale (=0.025) and the Hospital Anxiety and Depression Scale anxiety (=0.003) and depression (=0.029) scores were significantly associated with residence in more deprived areas (=0.003). In multivariate analysis, controlling for patient-level factors, living in more deprived areas was associated with more anxiety (=0.019). Higher ADI was associated with higher levels of anxiety among patients with advanced cancer. Geographic information could assist clinicians with providing geographically influenced social support strategies.