健康衰老和疾病中的剪接改变。
Splicing alterations in healthy aging and disease.
机构信息
The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA.
Department of Genetics and Genome Sciences, UConn Health, Farmington, Connecticut, USA.
出版信息
Wiley Interdiscip Rev RNA. 2021 Jul;12(4):e1643. doi: 10.1002/wrna.1643. Epub 2021 Feb 9.
Alternative RNA splicing is a key step in gene expression that allows generation of numerous messenger RNA transcripts encoding proteins of varied functions from the same gene. It is thus a rich source of proteomic and functional diversity. Alterations in alternative RNA splicing are observed both during healthy aging and in a number of human diseases, several of which display premature aging phenotypes or increased incidence with age. Age-associated splicing alterations include differential splicing of genes associated with hallmarks of aging, as well as changes in the levels of core spliceosomal genes and regulatory splicing factors. Here, we review the current known links between alternative RNA splicing, its regulators, healthy biological aging, and diseases associated with aging or aging-like phenotypes. This article is categorized under: RNA in Disease and Development > RNA in Disease RNA Processing > Splicing Regulation/Alternative Splicing.
选择性 RNA 剪接是基因表达的关键步骤，它允许从同一个基因生成具有不同功能的大量信使 RNA 转录本。因此，它是蛋白质组学和功能多样性的丰富来源。选择性 RNA 剪接的改变既发生在健康衰老过程中，也发生在许多人类疾病中，其中一些疾病表现出过早衰老表型或随年龄增长发病率增加。与年龄相关的剪接改变包括与衰老标志相关基因的差异剪接，以及核心剪接体基因和调节性剪接因子水平的变化。在这里，我们回顾了选择性 RNA 剪接及其调节因子与健康生物衰老以及与衰老或衰老样表型相关的疾病之间的已知联系。本文属于以下分类：RNA 在疾病与发育中的作用 > RNA 在疾病中的作用 > RNA 加工 > 剪接调控/选择性剪接。
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