巴西中心报道的儿童癌症患者突破性念珠菌血症。
Breakthrough Candidemia in Pediatric Patients With Cancer From a Brazilian Center.
机构信息
From the Department of Pediatrics.
Central Laboratory Division, University of São Paulo Medical School, São Paulo, Brazil.
出版信息
Pediatr Infect Dis J. 2021 Mar 1;40(3):251-254. doi: 10.1097/INF.0000000000003027.
We analyzed 19 cases of breakthrough candidemia from a referral pediatric cancer center in Brazil. All patients had neutropenia and were under antifungal prophylactic regimens, mostly micafungin (68%). Most of the patients were treated with amphotericin B formulations and 30-day mortality was 21%. Candida parapsilosis was the main etiologic agent (63%), and horizontal transmission was not evidenced by microsatellite analysis.
我们分析了巴西一家儿科癌症转诊中心的 19 例突破性念珠菌血症病例。所有患者均有中性粒细胞减少症，并接受抗真菌预防方案治疗，其中大多数使用米卡芬净（68%）。大多数患者接受两性霉素 B 制剂治疗，30 天死亡率为 21%。近平滑念珠菌是主要病原体（63%），微卫星分析未证实存在水平传播。
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