Dawson C A, Bronikowski T A, Linehan J H, Rickaby D A
Department of Physiology, Medical College of Wisconsin, Milwaukee 53226.
J Appl Physiol (1985). 1988 Jan;64(1):274-84. doi: 10.1152/jappl.1988.64.1.274.
The low-viscosity bolus method was used to determine the longitudinal distributions of vascular resistance and intravascular pressure with respect to cumulative vascular volume from the lobar artery to the lobar vein in isolated dog lung lobes near functional residual capacity under zone 3 conditions. We found that the resistance distribution had two modes, a larger one upstream and a smaller one downstream from a local minimum. Over the range of vascular pressures studied the total vascular resistance decreased and the vascular volume increased with increasing vascular pressure. However, the shape of the normalized resistance distribution was independent of vascular pressure. Comparisons of the resistance distributions with the distributions of arterial, capillary, and venous volumes suggest that the modes represent regions of relatively high resistance proximal and distal to the capillary bed. These results are consistent with the concept that within the lobar vascular bed the highest resistance per unit blood volume is in the smallest arteries and veins, as suggested by morphometric data from other sources.
采用低粘度团注法，在功能残气量附近，于3区条件下对离体犬肺叶从叶动脉至叶静脉的血管阻力和血管内压力相对于累积血管容积的纵向分布进行了测定。我们发现，阻力分布有两种模式，在局部最小值上游的一种较大，下游的一种较小。在所研究的血管压力范围内，总血管阻力随血管压力升高而降低，血管容积随血管压力升高而增加。然而，归一化阻力分布的形状与血管压力无关。将阻力分布与动脉、毛细血管和静脉容积分布进行比较表明，这两种模式分别代表毛细血管床近端和远端相对高阻力的区域。这些结果与其他来源的形态学数据所表明的概念一致，即在肺叶血管床内，单位血容量阻力最高的部位是最小的动脉和静脉。
