University of Health Sciences Turkey , Ahi Evren Chest and Cardiovascular Surgery Education and Research Hospital , Trabzon - Turquia.
Recep Tayyip Erdogan University, Faculty of Medicine , Rize - Turquia.
Arq Bras Cardiol. 2021 Mar;116(3):434-440. doi: 10.36660/abc.20190514.
Mean platelet volume (MPV), which is a simple measure of platelet activation, has recently become an interesting topic in cardiovascular research. Exercise-based cardiac rehabilitation (CR) is a comprehensive intervention that decreases mortality-morbidity in patients with coronary artery disease (CAD). Studies on the effects of exercise on platelet activation have yielded conflicting results.
The purpose of this study was to determine the effect of an exercise-based CR programs on MPV in patients with stable CAD.
The sample was composed of 300 consecutive stable CAD patients. The patients were divided into two groups: CR group (n = 97) and non-CR group (n = 203). Blood analysis was performed. Point-Biserial correlation measures were performed to show correlation between MPV change and CR. A p value of <0.05 was considered statistically significant.
The decrease in MPV was greater in the CR group than in the non-CR group [(-1.10(-1.40-(-0.90)) vs. (-0.10 (-2.00-0.00)); p< 0.001]. ΔMPV had a positive correlation with Δ neutrophil (r = 0.326, p < 0.001), ΔTG (r = 0.439, p < 0.001), ΔLDL-c (r = 0.478, p < 0.001), ΔWBC (r = 0.412, p < 0.001), and ΔCRP (r = 0.572, p < 0.001). A significant correlation was found between ΔMPV% and CR (r=0.750, p<0.001).
We were able to show that exercise-based CR has a strong relationship with MPV reduction in patients with CAD. We consider that decreased platelet activation with exercise-based CR might play an important role in reducing thrombotic risk in patients with stable CAD. (Arq Bras Cardiol. 2020; [online].ahead print, PP.0-0).
平均血小板体积（MPV）是血小板活化的一个简单指标，最近已成为心血管研究中的一个热门话题。基于运动的心脏康复（CR）是一种综合干预措施，可降低冠心病（CAD）患者的死亡率和发病率。关于运动对血小板活化影响的研究结果存在争议。
本研究旨在确定基于运动的 CR 方案对稳定型 CAD 患者血小板体积的影响。
该样本由 300 例连续的稳定型 CAD 患者组成。患者被分为两组：CR 组（n=97）和非-CR 组（n=203）。进行血液分析。点双列相关测量用于显示 MPV 变化与 CR 之间的相关性。p 值<0.05 被认为具有统计学意义。
CR 组的 MPV 下降幅度大于非-CR 组[（-1.10（-1.40-（-0.90））与（-0.10（-2.00-0.00））；p<0.001]。ΔMPV 与 Δ中性粒细胞（r = 0.326，p < 0.001）、ΔTG（r = 0.439，p < 0.001）、ΔLDL-c（r = 0.478，p < 0.001）、ΔWBC（r = 0.412，p < 0.001）和 ΔCRP（r = 0.572，p < 0.001）呈正相关。ΔMPV%与 CR 之间存在显著相关性（r=0.750，p<0.001）。
我们能够表明，基于运动的 CR 与 CAD 患者的 MPV 降低有很强的关系。我们认为，基于运动的 CR 降低血小板活化可能在降低稳定型 CAD 患者的血栓形成风险方面发挥重要作用。（Arq Bras Cardiol. 2020；[在线]。提前印刷，PP.0-0）。
