Petty W, Spanier S, Shuster J J
Department of Orthopaedics, University of Florida College of Medicine, Gainesville 32610.
J Bone Joint Surg Am. 1988 Apr;70(4):536-9.
An experiment was done in dogs to evaluate how efficient each of several techniques was in preventing infection after a total joint arthroplasty. The techniques that were studied were intraoperative irrigation with saline solution or with antimicrobial solution, perioperative systemic administration of antibiotics, and the addition of an antibiotic to bone cement. Irrigation with saline solution did not reduce the incidence of infection. A slight reduction was found after irrigation with neomycin solution and after systemic administration of cefazolin solution. The use of bone cement containing gentamicin caused a statistically significant reduction in the rate of infection; in fact, no infection developed in any animal that was treated with bone cement containing gentamicin. There was excellent but not absolute correlation between findings on culture that indicated the presence of infection and histological evidence of inflammation.
在狗身上进行了一项实验，以评估几种技术在全关节置换术后预防感染方面的有效性。所研究的技术包括术中用盐溶液或抗菌溶液冲洗、围手术期全身使用抗生素以及在骨水泥中添加抗生素。用盐溶液冲洗并未降低感染发生率。在用新霉素溶液冲洗和全身使用头孢唑林溶液后发现感染发生率略有降低。使用含庆大霉素的骨水泥使感染率有统计学意义的降低；事实上，用含庆大霉素的骨水泥治疗的任何动物都未发生感染。表明存在感染的培养结果与炎症的组织学证据之间存在良好但并非绝对的相关性。
