Shewmake K B, Talbert G E, Bowser-Wallace B H, Caldwell F T, Cone J B
University of Arkansas Medical Center, Little Rock 72205.
J Burn Care Rehabil. 1988 Jan-Feb;9(1):13-7. doi: 10.1097/00004630-198801000-00005.
This review was undertaken to elucidate the trends in copper, zinc, total serum protein, and ceruloplasmin levels in patients with thermal trauma. Medical records of pediatric and adult patients were retrospectively reviewed. The findings showed a significant linear decline in mean plasma copper, ceruloplasmin, and total serum protein during the first three days postburn, followed in general by a gradual rise in levels; however, patients with burns larger than 60% TBSA maintained copper, zinc, and ceruloplasmin levels significantly below the lower limits of normal during the observation period. Significant decrements in copper, zinc, total serum protein, and ceruloplasmin levels have been demonstrated in these patients. Trace metal determinations should be obtained in patients with significant burns soon after admission and routinely throughout their hospital course. Specific trace metal supplementation should be administered when indicated.
本综述旨在阐明热烧伤患者铜、锌、血清总蛋白和铜蓝蛋白水平的变化趋势。对儿科和成年患者的病历进行了回顾性分析。结果显示，烧伤后前三天，血浆铜、铜蓝蛋白和血清总蛋白的平均水平呈显著线性下降，随后总体呈逐渐上升趋势；然而，烧伤面积大于60%体表面积的患者在观察期内铜、锌和铜蓝蛋白水平显著低于正常下限。这些患者的铜、锌、血清总蛋白和铜蓝蛋白水平均有显著下降。对于严重烧伤患者，应在入院后尽快进行微量金属测定，并在整个住院过程中定期进行。如有指征，应给予特定的微量金属补充剂。
