Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.
Department of Medical Biochemistry and Biophysics, Umeå University, 90187 Umeå, Sweden.
Int J Mol Sci. 2021 Feb 8;22(4):1712. doi: 10.3390/ijms22041712.
The ability of cells to promote plasminogen activation on their surfaces is now well recognized, and several distinct cell surface proteins have been demonstrated to function as plasminogen receptors. Here, we review studies demonstrating that plasminogen bound to cells, in addition to plasminogen directly bound to fibrin, plays a major role in regulating fibrin surveillance. We focus on the ability of specific plasminogen receptors on eukaryotic cells to promote fibrinolysis in the in vivo setting by reviewing data obtained predominantly in murine models. Roles for distinct plasminogen receptors in fibrin surveillance in intravascular fibrinolysis, immune cell recruitment in the inflammatory response, wound healing, and lactational development are discussed.
细胞在其表面促进纤溶酶原激活的能力现在已经得到充分认可，并且已经证明几种不同的细胞表面蛋白可作为纤溶酶原受体发挥作用。在这里，我们综述了研究表明，细胞结合的纤溶酶原，除了直接结合纤维蛋白的纤溶酶原，在调节纤维蛋白监测方面发挥主要作用。我们主要通过在小鼠模型中获得的数据，重点讨论真核细胞上特定纤溶酶原受体在体内促进纤维蛋白溶解的能力。讨论了不同纤溶酶原受体在血管内纤维蛋白溶解中的纤维蛋白监测、炎症反应中的免疫细胞募集、伤口愈合和哺乳期发育中的作用。
