癌症患者念珠菌血症的危险因素：一项病例对照研究。
Risk factors for candidemia in cancer patients: a case-control study.
作者信息
Karabinis A, Hill C, Leclercq B, Tancrède C, Baume D, Andremont A
机构信息
Service de Microbiologie Médicale, Institut Gustave-Roussy, Villejuif, France.
出版信息
J Clin Microbiol. 1988 Mar;26(3):429-32. doi: 10.1128/jcm.26.3.429-432.1988.
Abstract
Risk factors for candidemia were analyzed in a case-control study of 30 cancer patients with candidemia and 58 controls. In a univariate analysis, previous surgery, neutropenia, central catheterization, chemotherapy, specific antibiotic treatments, and peripheral cultures positive for Candida spp. were associated with a significantly increased risk of candidemia. In a multivariate logistic model, the significant risk factors for candidemia were positive peripheral cultures for Candida spp. (P = 0.02), central catheterization (P = 0.03), and neutropenia (P = 0.05). These results should help to identify cancer patients with a high risk of candidemia, who should be given early systemic antifungal therapy.
摘要
在一项针对30例念珠菌血症癌症患者和58例对照的病例对照研究中，分析了念珠菌血症的危险因素。在单因素分析中，既往手术、中性粒细胞减少、中心静脉置管、化疗、特定抗生素治疗以及念珠菌属外周血培养阳性与念珠菌血症风险显著增加相关。在多因素逻辑模型中，念珠菌血症的显著危险因素为念珠菌属外周血培养阳性（P = 0.02）、中心静脉置管（P = 0.03）和中性粒细胞减少（P = 0.05）。这些结果应有助于识别念珠菌血症高危癌症患者，应对其尽早给予全身抗真菌治疗。
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