Cairns & Hinterland Mental Health and Alcohol Tobacco & Other Drugs Service, Cairns, Australia.
Mater Centre for Neurosciences, Mater Hospital, Brisbane, Australia.
J Geriatr Psychiatry Neurol. 2022 May;35(3):280-292. doi: 10.1177/0891988721993545. Epub 2021 Feb 11.
Depression and apathy can be significant problems in progressive supranuclear palsy (PSP). Using PRISMA guidelines, this systematic review examined prevalence estimates for depression and apathy in PSP, and, how different methods of definition may influence results. 29 studies meeting inclusion/exclusion criteria were identified: 12 on depression, 9 on apathy, and 8 on both. Studies were stratified according to whether a diagnostic criteria, rating scale or screening question methodology was employed. The weighted mean prevalence was 59.7% for depression (sample size = 473) and 58.3% for apathy (sample size = 858). Results for depression using diagnostic criteria or rating scales were similar whereas screening questions were associated with considerable inconsistency. Depression prevalence appeared to be influenced by apathy but not somatic symptoms. Most apathy studies relied only on a screening question method. Depression and apathy are common in PSP but there is a need for consensus on how they are defined (both tools and cut-off scores). In particular, more studies probing apathy in greater detail than a simple screening question are required.
抑郁和淡漠在进行性核上性麻痹（PSP）中可能是严重的问题。本系统评价采用 PRISMA 指南，检查了 PSP 中抑郁和淡漠的患病率估计，以及不同的定义方法如何影响结果。符合纳入/排除标准的 29 项研究被确定：12 项关于抑郁，9 项关于淡漠，8 项同时涉及抑郁和淡漠。研究根据是否采用诊断标准、评分量表或筛查问题方法进行分层。抑郁的加权平均患病率为 59.7%（样本量=473），淡漠为 58.3%（样本量=858）。使用诊断标准或评分量表的抑郁结果相似，而筛查问题则存在相当大的不一致。抑郁的患病率似乎受淡漠影响，但不受躯体症状影响。大多数淡漠研究仅依赖于筛查问题方法。抑郁和淡漠在 PSP 中很常见，但需要就如何定义它们（包括工具和截断值）达成共识。特别是，需要更多的研究更详细地探讨淡漠，而不仅仅是一个简单的筛查问题。
