Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", Center for Neurodegenerative Diseases (CEMAND), University of Salerno, Neuroscience Section, Via Allende, 84081, Baronissi (Salerno), Italy.
Center for Magnetic Resonance Research (CMRR), Department of Radiology, University of Minnesota, 2021 6th St. SE, Minneapolis, MN, 55455, USA.
J Neural Transm (Vienna). 2023 Oct;130(10):1259-1267. doi: 10.1007/s00702-023-02676-9. Epub 2023 Aug 3.
Neuropsychiatric symptoms are intrinsic to Progressive Supranuclear Palsy (PSP) and a spoonful of studies investigated their imaging correlates. Describe (I) the frequency and severity of neuropsychiatric symptoms in PSP and (II) their structural imaging correlates. Twenty-six PSP patients underwent Neuropsychiatric Inventory (NPI) and brain 3D T1-weighted MRI. Spearman's rho with Bonferroni correction was used to investigate correlations between NPI scores and volumes of gray matter regions. More than 80% of patients presented at least one behavioral symptom of any severity. The most frequent and severe were depression/dysphoria, apathy, and irritability/lability. Significant relationships were found between the severity of irritability and right pars opercularis volume (p < 0.001) as well as between the frequency of agitation/aggression and left lateral occipital volume (p < 0.001). Depression, apathy, and irritability are the most common neuropsychiatric symptoms in PSP. Moreover, we found a relationship between specific positive symptoms as irritability and agitation/aggression and greater volume of the right pars opercularis cortex and lower volume of the left occipital cortex, respectively, which deserve further investigations.
神经精神症状是进行性核上性麻痹 (PSP) 的固有症状，有一些研究探讨了其影像学相关性。描述 (I) PSP 中神经精神症状的频率和严重程度，以及 (II) 其结构影像学相关性。26 名 PSP 患者接受了神经精神疾病问卷 (NPI) 和大脑 3D T1 加权 MRI 检查。采用 Spearman 秩相关系数和 Bonferroni 校正法来研究 NPI 评分与灰质区域体积之间的相关性。超过 80%的患者至少出现过一种任何严重程度的行为症状。最常见和最严重的是抑郁/烦躁、淡漠和易怒/不稳定。发现易怒严重程度与右侧岛盖部体积之间存在显著相关性 (p < 0.001)，以及激越/攻击频率与左侧外侧枕叶体积之间存在显著相关性 (p < 0.001)。抑郁、淡漠和易怒是 PSP 中最常见的神经精神症状。此外，我们发现特定的阳性症状，如易怒和激越/攻击，与右侧岛盖部皮质体积增加和左侧枕叶皮质体积减少之间存在相关性，这值得进一步研究。
