Department of Anesthesiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Department of Neurobiology, Capital Medical University, Beijing, China.
Mol Pain. 2021 Jan-Dec;17:1744806921990944. doi: 10.1177/1744806921990944.
Pain is a serious clinical challenge, and is associated with a significant reduction in quality of life and high financial costs for affected patients. Research efforts have been made to explore the etiological basis of pain to guide the future treatment of patients suffering from pain conditions. Findings from studies using KA (kainate) receptor agonist, antagonists and receptor knockout mice suggested that KA receptor dysregulation and dysfunction may govern both peripheral and central sensitization in the context of pain. Additional evidence showed that KA receptor dysfunction may disrupt the finely-tuned process of glutamic acid transmission, thereby contributing to the onset of a range of pathological contexts. In the present review, we summarized major findings in recent studies which examined the roles of KA receptor dysregulation in nociceptive transmission and in pain. This timely overview of current knowledge will help to provide a framework for future developing novel therapeutic strategies to manage pain.
疼痛是一个严重的临床挑战，它会导致患者生活质量显著下降，并带来高昂的经济负担。研究人员一直在努力探索疼痛的病因基础，以指导未来对疼痛患者的治疗。使用红藻氨酸（KA）受体激动剂、拮抗剂和受体敲除小鼠进行的研究结果表明，KA 受体失调和功能障碍可能控制疼痛情况下的外周和中枢敏化。其他证据表明，KA 受体功能障碍可能破坏谷氨酸传递的精细调节过程，从而导致一系列病理情况的发生。在本综述中，我们总结了最近研究中关于 KA 受体失调在伤害性传递和疼痛中的作用的主要发现。这一及时的知识概述将有助于为未来开发新的治疗疼痛的策略提供框架。
