Department of Anesthesia, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Department of Anesthesiology & Perioperative Medicine, Tufts Medical Center and Tufts University School of Medicine, Boston, USA.
Biol Sex Differ. 2021 Feb 10;12(1):22. doi: 10.1186/s13293-021-00364-5.
Sensory perception and emotional disorders are disproportionally represented in men and women and are thus thought to be modulated by different sex hormones in various conditions. Among the most important hormones perceived to affect sensory processing and transduction is estrogen. Numerous previous researchers have endeavored to demonstrate that estrogen is capable of modulating the activity of sensory neurons in peripheral and central sites in female, male, or castrated animals. However, the underlying mechanisms of its modulation of neuronal activity are somewhat unclear. In the present review, we discuss the possible cellular and molecular mechanisms involved in the modulation of nociception by estrogen.
感觉感知和情绪障碍在男性和女性中不成比例地存在，因此被认为在各种情况下受到不同性激素的调节。在被认为影响感觉处理和转导的最重要激素中，雌激素是其中之一。许多先前的研究人员都致力于证明雌激素能够调节雌性、雄性或去势动物外周和中枢部位感觉神经元的活性。然而，其对神经元活性调节的潜在机制尚不完全清楚。在本综述中，我们讨论了雌激素调节痛觉的可能细胞和分子机制。
