Erdrich Sharon, Hawrelak Jason A, Myers Stephen P, Harnett Joanna E
Faculty of Medicine and Health, School of Pharmacy, The University of Sydney, Science Road, Camperdown, Sydney, New South Wales 2006, Australia.
College of Health and Medicine, University of Tasmania, Hobart, Tasmania, Australia.
Therap Adv Gastroenterol. 2020 Dec 8;13:1756284820977402. doi: 10.1177/1756284820977402. eCollection 2020.
Fibromyalgia and functional gastrointestinal disorders (FGID) including irritable bowel syndrome (IBS) are common conditions presenting in clinical settings and are more prevalent in women. While the relationship between IBS and fibromyalgia has been demonstrated, a review of the prevalence of the broader group of FGID in adults with fibromyalgia has not been undertaken. The aim of this review was to systematically review the published literature, identifying the comorbidity of FGID in people with fibromyalgia, and to discuss the clinical implications, limitations of current research and areas of interest for future research.
Medline, Embase, CINAHL and Web of Science were searched during June 2019. Results were screened for original research articles meeting established criteria for identification of FGID in adults diagnosed with fibromyalgia.
A total of 14 studies involving 1340 adults with fibromyalgia, 363 healthy controls and 441 adults with other pathologies were included in this review. Only 1 of the 14 studies included surveyed the full range of FGID . Functional gut disorders were matched to Rome II criteria for reporting and comparison. In addition to increased abdominal pain and functional bloating or gas, IBS of mixed-pattern and constipation-types appear to be more prevalent than diarrhoea-predominant IBS in adults with fibromyalgia.
This review confirms previous reports that IBS is common in people living with fibromyalgia and suggests that IBS-mixed and constipation types predominate. An association with a range of FGID other than IBS is suggested, but data are limited. Research exploring the association between fibromyalgia and functional gastrointestinal dysfunction beyond IBS are warranted.
纤维肌痛和功能性胃肠疾病（FGID），包括肠易激综合征（IBS），是临床常见病症，在女性中更为普遍。虽然IBS与纤维肌痛之间的关系已得到证实，但尚未对纤维肌痛成年患者中更广泛的FGID群体的患病率进行综述。本综述的目的是系统回顾已发表的文献，确定纤维肌痛患者中FGID的合并症，并讨论临床意义、当前研究的局限性以及未来研究的关注领域。
于2019年6月检索了Medline、Embase、CINAHL和科学网。对结果进行筛选，以获取符合既定标准的、用于识别诊断为纤维肌痛的成年患者中FGID的原始研究文章。
本综述共纳入了14项研究，涉及1340名患有纤维肌痛的成年人、363名健康对照者和441名患有其他疾病的成年人。14项研究中只有1项对FGID的所有类型进行了调查。功能性肠道疾病根据罗马II标准进行报告和比较。除腹痛加剧和功能性腹胀或肠胃胀气外，在患有纤维肌痛的成年人中，混合型和便秘型IBS似乎比腹泻型IBS更为普遍。
本综述证实了先前的报道，即IBS在纤维肌痛患者中很常见，并表明混合型和便秘型IBS占主导。提示与IBS以外的一系列FGID存在关联，但数据有限。有必要开展研究探索纤维肌痛与IBS以外的功能性胃肠功能障碍之间的关联。
