Esarte Palomero Orhi, Cunningham Ashley L, Davies Bryan W, Jones Richard A
Department of Chemistry, The University of Texas at Austin.
Department of Molecular Biosciences, The University of Texas at Austin.
Inorganica Chim Acta. 2021 Mar 1;517. doi: 10.1016/j.ica.2020.120152. Epub 2020 Nov 27.
Three new coinage metal carbene complexes of silver and gold were synthesized from a thiamine inspired ligand. The compounds were characterized by HRMS, NMR spectroscopy (H, F, P and C), FT-IR and elemental analysis. The coordination environment around the metal centers was correlated to the diffusion coefficients obtained from DOSY-NMR experiments and was in agreement with the nuclearity observed in the solid-state by single crystal X-ray crystallography. The silver and gold carbene compounds were subjected to MIC studies against a panel of pathogenic bacteria, including multidrug resistant strains, with the gold carbene derivative showing the most potent antimicrobial activity against Gram-positive methicillin resistant (MRSA).
通过一种受硫胺素启发的配体合成了三种新型的银和金的铸币金属卡宾配合物。这些化合物通过高分辨质谱（HRMS）、核磁共振光谱（H、F、P和C）、傅里叶变换红外光谱（FT-IR）和元素分析进行了表征。金属中心周围的配位环境与通过扩散排序核磁共振（DOSY-NMR）实验获得的扩散系数相关，并且与单晶X射线晶体学在固态中观察到的核数一致。对银和金卡宾化合物针对一系列致病细菌（包括多重耐药菌株）进行了最小抑菌浓度（MIC）研究，其中金卡宾衍生物对革兰氏阳性耐甲氧西林金黄色葡萄球菌（MRSA）显示出最强的抗菌活性。
