Department of Chemistry and Biochemistry, University of Texas at Austin, University Station, A5300, Austin, TX 78712, USA.
Molecules. 2011 Mar 9;16(3):2285-92. doi: 10.3390/molecules16032285.
The AgCl, AgOAc, AuCl, and AuOAc complexes of the new bis(imino)acenaphthene(BIAN)-supported N-heterocyclic carbene ligand and the precursor imidazolium salt have been investigated with respect to their antimicrobial activities against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Psudomonas aeruginosa. The most active antimicrobial is the precursor imidazolium salt, which has a minimum inhibitory concentration (MIC) value of <40 μg/mL. The MIC values for the silver complexes IPr(BIAN)AgCl and IPr(BIAN)AgOAc against Gram-positive S. aureus are comparable to that for AgNO₃, while those against Gram-negative E. coli and P.aeroginosa are significantly larger. Similar behavior was evident for the gold acetate complex IPr(BIAN)AuOAc. However, in the case of the gold chloride analogue, the MIC values are virtually identical for both the Gram-positive and the Gram-negative bacteria.
已经研究了新型双（亚氨基）-占吨（BIAN）-支载 N-杂环卡宾配体和前体咪唑鎓盐的 AgCl、AgOAc、AuCl 和 AuOAc 配合物的抗菌活性，针对金黄色葡萄球菌、枯草芽孢杆菌、大肠杆菌和铜绿假单胞菌。最具活性的抗菌物质是前体咪唑鎓盐，其最低抑菌浓度（MIC）值小于 40 μg/mL。AgCl 和 AgOAc 配合物 IPr(BIAN)AgCl 和 IPr(BIAN)AgOAc 对革兰氏阳性菌金黄色葡萄球菌的 MIC 值与 AgNO₃相当，而对革兰氏阴性菌大肠杆菌和铜绿假单胞菌的 MIC 值则明显较大。类似的行为在醋酸金配合物 IPr(BIAN)AuOAc 中也很明显。然而，对于金氯化物类似物，其 MIC 值在革兰氏阳性和革兰氏阴性细菌中几乎相同。
