Victor Bloniecki, Karolinska Institute, Karolinska Uinversity Hospital, Eugeniavägen 3, SE-17176, Stockholm, Sweden. Tel.: +46 70-726 82 20; Email:
J Prev Alzheimers Dis. 2021;8(2):127-134. doi: 10.14283/jpad.2021.2.
Due to an ageing demographic and rapid increase of cognitive impairment and dementia, combined with potential disease-modifying drugs and other interventions in the pipeline, there is a need for the development of accurate, accessible and efficient cognitive screening instruments, focused on early-stage detection of neurodegenerative disorders.
In this proof of concept report, we examine the validity of a newly developed digital cognitive test, the Geras Solutions Cognitive Test (GCST) and compare its accuracy against the Montreal Cognitive Assessment (MoCA).
106 patients, referred to the memory clinic, Karolinska University Hospital, due to memory complaints were included. All patients were assessed for presence of neurodegenerative disorder in accordance with standard investigative procedures. 66% were diagnosed with subjective cognitive impairment (SCI), 25% with mild cognitive impairment (MCI) and 9% fulfilled criteria for dementia. All patients were administered both MoCA and GSCT. Descriptive statistics and specificity, sensitivity and ROC curves were established for both test.
Mean score differed significantly between all diagnostic subgroups for both GSCT and MoCA (p<0.05). GSCT total test time differed significantly between all diagnostic subgroups (p<0.05). Overall, MoCA showed a sensitivity of 0.88 and specificity of 0.54 at a cut-off of <=26 while GSCT displayed 0.91 and 0.55 in sensitivity and specificity respectively at a cut-off of <=45.
This report suggests that GSCT is a viable cognitive screening instrument for both MCI and dementia.
由于人口老龄化以及认知障碍和痴呆症的迅速增加，再加上潜在的疾病修饰药物和其他干预措施正在研发中，因此需要开发准确、易于获取和高效的认知筛查工具，专注于早期发现神经退行性疾病。
在本概念验证报告中，我们研究了一种新开发的数字认知测试——Geras Solutions Cognitive Test（GCST）的有效性，并将其准确性与 Montreal Cognitive Assessment（MoCA）进行比较。
106 名因记忆问题而被转诊到卡罗林斯卡大学医院记忆诊所的患者被纳入本研究。所有患者均按照标准检查程序评估是否存在神经退行性疾病。66%的患者被诊断为主观认知障碍（SCI），25%的患者被诊断为轻度认知障碍（MCI），9%的患者符合痴呆症的诊断标准。所有患者均接受了 MoCA 和 GSCT 测试。为两种测试建立了描述性统计、特异性、敏感性和 ROC 曲线。
GSCT 和 MoCA 的平均得分在所有诊断亚组之间存在显著差异（p<0.05）。GSCT 的总测试时间在所有诊断亚组之间也存在显著差异（p<0.05）。总体而言，MoCA 的灵敏度为 0.88，特异性为 0.54，截断值为 <=26；而 GSCT 的灵敏度和特异性分别为 0.91 和 0.55，截断值为 <=45。
本报告表明，GSCT 是一种用于 MCI 和痴呆症的可行认知筛查工具。
