Am J Epidemiol. 2021 Jun 1;190(6):1064-1074. doi: 10.1093/aje/kwab027.
The role of lifestyle in development of herpes zoster remains unclear. We examined whether smoking status, alcohol consumption, body mass index, or physical activity were associated with zoster risk. We followed a population-based cohort of 101,894 respondents to the 2010 Danish National Health Survey (baseline, May 1, 2010) until zoster diagnosis, death, emigration, or July 1, 2014, whichever occurred first. We computed hazard ratios for zoster associated with each exposure, using Cox regression with age as the time scale and adjusting for potential confounders. Compared with never smokers, hazards for zoster were increased in former smokers (1.17, 95% confidence interval (CI): 1.06, 1.30), but not in current smokers (1.00, 95% CI: 0.89, 1.13). Compared with low-risk alcohol consumption, neither intermediate-risk (0.95, 95% CI: 0.84, 1.07) nor high-risk alcohol consumption (0.99, 95% CI: 0.85, 1.15) was associated with zoster. We also found no increased hazard associated with weekly binge drinking versus not (0.93, 95% CI: 0.77, 1.11). Risk of zoster varied little by body mass index (referent = normal weight) and physical activity levels (referent = light level), with hazard ratios between 0.96 and 1.08. We observed no dose-response association between the exposures and zoster. The examined lifestyle and anthropometric factors thus were not risk factors for zoster.
生活方式在带状疱疹的发展中的作用仍不清楚。我们研究了吸烟状况、饮酒、体重指数或身体活动是否与带状疱疹风险相关。我们对参加 2010 年丹麦全国健康调查的基于人群的队列中的 101894 名应答者进行了随访（基线，2010 年 5 月 1 日），直至带状疱疹诊断、死亡、移民或 2014 年 7 月 1 日，以先发生者为准。我们使用 Cox 回归，以年龄为时间尺度，并调整潜在的混杂因素，计算了每种暴露与带状疱疹相关的风险比。与从不吸烟者相比，曾经吸烟者的带状疱疹风险增加（1.17，95%置信区间：1.06，1.30），但当前吸烟者的风险没有增加（1.00，95%置信区间：0.89，1.13）。与低风险饮酒相比，中等风险（0.95，95%置信区间：0.84，1.07）和高风险饮酒（0.99，95%置信区间：0.85，1.15）均与带状疱疹无关。我们还发现每周 binge 饮酒与不饮酒相比，带状疱疹的风险没有增加（0.93，95%置信区间：0.77，1.11）。体重指数（参考值=正常体重）和身体活动水平（参考值=轻度水平）与带状疱疹风险差异不大，风险比在 0.96 到 1.08 之间。我们没有观察到暴露与带状疱疹之间存在剂量反应关系。因此，所检查的生活方式和人体测量因素不是带状疱疹的危险因素。
