Department of Urology, School of Medicine, University of St. Gallen, Rorschacherstrasse 95, 9007, St. Gallen, Switzerland.
Department of Urology, Musgrove Park Hospital, Somerset Foundation Trust, Taunton, UK.
World J Urol. 2021 Jul;39(7):2301-2306. doi: 10.1007/s00345-021-03601-z. Epub 2021 Feb 10.
Prostatic artery embolization (PAE) has emerged as a truly minimally invasive treatment option for patients with lower urinary tract symptoms presumed secondary to benign prostatic obstruction (LUTS/BPO) over the last few years and is now supported by evidence-based international guidelines. Here, we provide an overview on the profile of PAE based on the most relevant and recent literature.
A comprehensive review of literature on PAE was conducted on PubMed-Medline. The most relevant literature was summarized narratively.
While there is still a lack of long-term data, efficacy and safety data have been published for the short to mid-term. As with any minimally invasive technique, relief of bladder outlet obstruction is less pronounced after PAE compared to more invasive resective techniques. This is likely to be associated with higher re-intervention rates during the longer term. However, due to its beneficial safety profile, PAE represents an interesting option for many patients and could fill a niche between pharmacotherapy and formal surgical intervention. Given its unique treatment approach, i.e. endovascular instead of transurethral, PAE has a clearly different profile compared to other minimally invasive treatments. Performance with local anesthesia with possible continuation of anticoagulant drugs and no upper prostate size limit are the most important advantages of PAE.
PAE represents a valuable supplement in the treatment armamentarium of LUTS/BPH if patients are selected appropriately.
前列腺动脉栓塞术 (PAE) 在过去几年中作为一种真正的微创治疗选择,针对因良性前列腺梗阻 (LUTS/BPO) 而出现下尿路症状的患者,已被纳入国际循证指南。在此,我们根据最新的相关文献,概述了 PAE 的特点。
在 PubMed-Medline 上进行了 PAE 的文献全面综述。对最相关的文献进行了叙述性总结。
虽然长期数据仍然缺乏,但已发表了短期至中期的疗效和安全性数据。与任何微创技术一样,与更具侵入性的切除技术相比,PAE 对膀胱出口梗阻的缓解程度较低。这可能与长期内更高的再次介入率有关。然而,由于其有益的安全性,PAE 对许多患者来说是一个有趣的选择,并可能填补药物治疗和正式手术干预之间的空白。鉴于其独特的治疗方法,即血管内而非经尿道,PAE 与其他微创治疗方法的特点明显不同。局部麻醉下进行、可能继续使用抗凝药物以及没有前列腺上缘大小限制,是 PAE 的最重要优势。
如果患者选择适当,PAE 将成为治疗 LUTS/BPH 的重要补充手段。